Table 2 Substrate-mediated inhibition of Pdr5 ATPase activity and substrate partition coefficient.
From: In vitro NTPase activity of highly purified Pdr5, a major yeast ABC multidrug transporter
Purified Pdr5 | Pdr5 in plasma membranea | Ki, detergent: Ki, PM | Partition coefficient | |
|---|---|---|---|---|
Substrate | Ki [µM] | Ki [µM] | logP | |
Rhodamin 6 G | 3.2 ± 0.2 | 0.6 ± 0.1 | 5.3 | 6.52 |
Ketoconazol | 22.73 ± 2.1 | 5.4 ± 0.8 | 4.2 | 4.06 |
