Figure 8
From: Interplay of fibroblasts with anaplastic tumor cells promotes follicular thyroid cancer progression
Proposed model describing the paracrine loop existing between anaplastic thyroid tumor cells and stromal fibroblasts in TC. Soluble signals derived from ATC cells promotes the up-regulation of pSrc and pAkt in human fibroblasts, leading to increased cell proliferation, secretory functions and metabolic reprogramming of fibroblasts, consistent with the induction of CAF phenotype. Moreover, CM from activated fibroblasts promoted thyroid cell proliferation and invasion, thereby increasing TC progression.
