Figure 3
From: Periodontal treatment prevents arthritis in mice and methotrexate ameliorates periodontal bone loss
Macroscopic signs of arthritis were paralleled by overt histological inflammation. (A,D) Representative images of an unaffected and an affected (Score = 15) hind paw. (B,C) HE-stained thin-sections of the unaffected paw at 12.5x and 200x magnifications, respectively. (E,F) HE-stained thin-sections of the affected paw at 12.5x and 200x magnifications, showing massive leukocyte infiltration and cartilage destruction. Boxed areas in B and E denote the areas of magnification shown in C and F.
