Figure 4
From: Periodontal treatment prevents arthritis in mice and methotrexate ameliorates periodontal bone loss
RA-treatment ameliorates periodontitis in mice. (A) Representative 2D and 3D images of the alveolar bone loss (blue area) found in untreated (Ctrl) and treated mice. Arrows indicate the cemento-enamel junction (CEJ) and the alveolar bone crest (ABC). (B) The upper left panel illustrates the axial plane of the right hemi-mandible and its three molars as well as the defined region of interest (ROI) for each tooth. The lower left panel indicates 3 geometrically distributed measurement planes per tooth, in which the bone loss was assessed. Right panel displays the measurement of the distance from CEJ to the ABC at the lingual and the buccal side of each tooth. (B) Shows the periodontal bone loss measured as an increased distance between the CEJ and ABC. The control group (Ctrl) received no therapeutic intervention. Numbers of mice per group were Ctrl n = 8, CE n = 8, ME n = 8, CL n = 7, ML n = 7, MTX n = 8. Asterisks denote statistically significant differences resulting from ANOVA. ***p < 0.001.
