Figure 3
Peli1 deficiency suppresses LPS-induced neuroinflammation in substantia nigra. (a) Experimental diagram showing the procedure of LPS-induced neuroinflammation in SN and the time points when to collect tissue sample for QPCR or histological analysis. (b) QPCR analysis of relative mRNA expression for Nos2 and the indicated proinflammatory genes in the SN of WT and Peli1-KO mice that stereotaxically injected with 2 μl PBS or LPS (5 μg/ml). The gene expression were normalized to a reference gene Actb (encoding β-actin) and showed as the relative value to Actb in bar graphs. Data with error bars represent mean ± SD. Each panel is representative of at least three independent experiment. **P < 0.01 as determined by two-way ANOVA with a Bonferroni post test (b).
