Figure 3
From: Hes1 expression in mature neurons in the adult mouse brain is required for normal behaviors
Inactivating Hes1 in excitatory neurons leads to abnormal retention of fear memory and a slight increase in anxiety level. (a) Bar plots showing freezing time of wild-type control (black, n = 17) and Math2-Cre;Hes1 cKO (gray, n = 17) mice during fear conditioning, context recall, and cued recall of the fear conditioning test as well as before fear conditioning (baseline). Interval between 1st and 2nd tests was 6 months. Data are presented as mean ± SEM; *p < 0.05; two tailed Student’s t-test. (b) Line plots showing total distance traveled and time spent in the center during the open field test for wild-type control (black, n = 17) and Hes1 cKO (gray, n = 17) mice. Data are presented as mean ± SEM; the p-values indicate a genotype effect in the two-way repeated measures ANOVA.
