Figure 8
A model on actions of G4 and Rif1 in chromatin organization. G4 structures generated on the genomes may stochastically interact with each other through their self-association ability. A strong binder of Rif1 (indicated by pink circles), which probably forms more stable G4, would be recognized and bound by Rif1. This may stabilize the transient interactions between multiple G4s through its G4 binding and oligomerization abilities, leading to formation of chromatin compartment related to replication timing. The length of chromatin loop in the drawing is not to the actual size, which should be much larger.
