Table 1 Twin cohort details.
MZ set | ALS | Disease Status | Sex | Mutation | Age of onset | Age at samplingA | Disease duration (months) | 450K samples (n)B | RNA-Seq samples (n) | EpiTYPER samples (n) |
|---|---|---|---|---|---|---|---|---|---|---|
Female SALS twin set | SALS | ALS | F | 42.7 | 43.5–45.1 | Alive at 51 months | 7(+1) | — | — | |
Unaffected | F | 43.9–45.1 | 7(+1) | — | — | |||||
Male SALS twin set | SALS | ALS | M | 78.5 | 79.8–80.2 | 28.4 | 3(+1) | 3 | — | |
Unaffected | M | 79.8–80.2 | 3(+1) | 3 | — | |||||
C9orf72 twin set | FALS | ALS | M | C9orf72 HRE | 52 | 54.1 | 36 | 1 | — | 1 |
Asymptomatic | M | C9orf72 HRE | 54.3–55 | 2 | — | 2 | ||||
SOD1 triplet set | FALS | ALS | F | SOD1 p.I114T | 50 | 50.3 | Unknown | 1 | — | 1 |
Asymptomatic | F | SOD1 p.I114T | 50.3 | 1 | — | 1 | ||||
Asymptomatic | F | SOD1 p.I114T | 50.3 | 1 | — | 1 | ||||
Control twin set 1 | NA | Control | F | NA | 46.1 | NA | 1 | — | ||
Control | F | 46.1 | 1 | — | ||||||
Control twin set 2 | NA | Control | M | NA | 36.8 | NA | — | — | 1 | |
Control | M | 31.8–43.0C | — | — | 3C |
