Figure 2 | Scientific Reports

Figure 2

From: Volumetric optoacoustic tomography enables non-invasive in vivo characterization of impaired heart function in hypoxic conditions

Figure 2

Staining for α-smooth-muscle actin of murine lungs. Formalin fixed and paraffin embedded (FFPE) lung sections derived from normoxic (Nx) or hypoxic (Hx) mice were stained for α-smooth-muscle actin and the number of muscularized small vessels (<30 µm) was counted. (A) Small muscularized vessels are indicated with arrows. (B) Graph shows the number of small muscularized vessels per mm2 lung tissue, assembled from three regions of interest per lung (n = 3, **p < 0.01 Hx vs. Nx). (C) The Fulton index as measure of right ventricular hypertrophy was determined as ratio between mass of the right (RV) and left ventricle (LV) with septum (S) (n = 3, *p < 0.05 Hx vs. Nx).

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