Table 5 Estimates of the effect of indoleamine 2,3-dioxygenase 1 (IDO1) protein and kynurenine--oxoglutarate transaminase 3 (KAT3) protein on prostate cancer, lung and bronchus cancer and breast cancer using Mendelian Randomization with different methods.
From: Indoleamine 2,3-dioxygenase and ischemic heart disease: a Mendelian Randomization study
Outcome | Exposure (SD) | SNPs | Method | OR | 95%CI | P value | Cochran’s Q statistic (p-value) | MR-Egger | |
|---|---|---|---|---|---|---|---|---|---|
Intercept p value | I2 | ||||||||
prostate cancer | IDO1 | 3a | IVW | 0.96 | 0.93, 0.99 | 0.01 | 4.43 (0.11) | 0.38 | 93.6% |
MR-Egger | 0.89 | 0.74, 1.06 | 0.19 | ||||||
WM | 0.96 | 0.92, 1.00 | 0.04 | ||||||
8 | IVW | 0.96 | 0.93, 0.99 | 0.01 | 8.25 (0.31) | 0.44 | 94.4% | ||
MR-Egger | 0.94 | 0.87, 1.01 | 0.08 | ||||||
WM | 0.96 | 0.92, 1.00 | 0.03 | ||||||
MR-PRESSO | 0.96 | 0.93, 0.99 | 0.01 | ||||||
KAT3 | 2b | IVW | 0.98 | 0.92, 1.03 | 0.42 | 4.26 (0.04) | |||
15 | IVW | 1.00 | 0.95, 1.04 | 0.83 | 28.88 (0.01) | 0.85 | 36.4% | ||
MR-Egger | 0.99 | 0.90, 1.08 | 0.79 | ||||||
WM | 1.00 | 0.95, 1.05 | 0.95 | ||||||
MR-PRESSO | 1.00 | 0.95, 1.04 | 0.84 | ||||||
lung and bronchus cancer | IDO1 | 3a | IVW | 1.04 | 0.93, 1.17 | 0.48 | 0.25 (0.88) | 0.81 | 92.9% |
MR-Egger | 0.99 | 0.66, 1.51 | 0.98 | ||||||
WM | 1.04 | 0.92, 1.18 | 0.52 | ||||||
8 | IVW | 1.00 | 0.90, 1.11 | 0.94 | 5.83 (0.56) | 0.11 | 94.5% | ||
MR-Egger | 1.18 | 0.94, 1.50 | 0.16 | ||||||
WM | 1.03 | 0.91, 1.17 | 0.66 | ||||||
MR-PRESSO | 1.00 | 0.91, 1.10 | 0.94 | ||||||
KAT3 | 2b | IVW | 1.00 | 0.81, 1.24 | 0.97 | 0.31 (0.58) | |||
15 | IVW | 1.09 | 0.96, 1.22 | 0.18 | 14.36 (0.42) | 0.66 | 37.3% | ||
MR-Egger | 1.03 | 0.79, 1.34 | 0.82 | ||||||
WM | 1.05 | 0.89, 1.24 | 0.54 | ||||||
MR-PRESSO | 1.09 | 0.96, 1.22 | 0.18 | ||||||
breast cancer | IDO1 | 3a | IVW | 0.99 | 0.97, 1.02 | 0.54 | 1.48 (0.48) | 0.26 | 93.3% |
MR-Egger | 0.94 | 0.87, 1.03 | 0.21 | ||||||
WM | 0.99 | 0.96, 1.02 | 0.52 | ||||||
8 | IVW | 0.99 | 0.97, 1.01 | 0.37 | 7.55 (0.37) | 0.80 | 94.3% | ||
MR-Egger | 0.98 | 0.93, 1.04 | 0.56 | ||||||
WM | 0.98 | 0.95, 1.01 | 0.21 | ||||||
MR-PRESSO | 0.99 | 0.97, 1.01 | 0.38 | ||||||
KAT3 | 2b | IVW | 1.03 | 0.98, 1.08 | 0.19 | 12.62 (<0.01) | |||
15 | IVW | 1.00 | 0.97, 1.04 | 0.89 | 26.80 (0.02) | 0.54 | 33.4% | ||
MR-Egger | 0.98 | 0.91, 1.06 | 0.63 | ||||||
WM | 0.99 | 0.95, 1.03 | 0.51 | ||||||
MR-PRESSO (corrected) | 0.99 | 0.96, 1.01 | 0.29 | ||||||
