Figure 2 | Scientific Reports

Figure 2

From: Homeostatic pruning and activity of epidermal nerves are dysregulated in barrier-impaired skin during chronic itch development

Figure 2

Epidermal nerve fibers are of Nav1.8-tdTomato+ sensory neurons, which are necessary for itch in Spade mice. (a) Whole-mount confocal fluorescence images of the ear skin from Nav1.8-tdTomato and Nav1.8-tdTomato/DTA mice. Nav1.8-tdTomato+ PGP9.5+ nerves and Nav1.8-tdTomato− PGP9.5+ nerves are shown in vertical (top, 33 μm projection depth) and horizontal (bottom, 28.4 μm projection depth) projection images. See also Supplementary Fig. 2. (b) The number of scratching strokes by the hind paws of the indicated mice after wearing Elizabethan collars. The data are shown as the mean ± s.e.m. (n = 3–4). *p < 0.05, **p < 0.01.

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