Figure 2
From: Two pathways for venom toxin entry consequent to injection of an Australian elapid snake venom
Hind limb cooling slows the onset but does not reduce area under the curve of venom concentrations. (A) Mean serum venom concentration measured before and at set times after subcutaneous injection of PTx venom at 0.15 mg/kg into a hind paw of anaesthetised rats without (mean leg temperature 34 ± 1 °C) or with application of hind limb cooling (see Methods) to a mean steady state leg temperature of 4 °C (range 2–6 °C). (B) Mean time-course of leg cooling. Serum venom concentrations were determined from 0.2 ml blood samples taken at the times shown. Data shown as mean ± SEM (#P < 0.0001, +P < 0.001 two-way ANOVA and unpaired multiple two-tailed t-test; n = 6 for all data points).
