Table 3 List of launched drugs targeting DEGs associated with viral host response and Alzheimer’s Disease or Parkinson’s Disease.
Target | EBV_DEG | CMV_DEG | HHV6_DEG | Drug | Disease | Molecule type |
|---|---|---|---|---|---|---|
VDR | x | ALFACALCIDOL | diabetic nephropathy | Small molecule | ||
VDR | x | CHOLECALCIFEROL | type I diabetes mellitus; Parkinson’s Disease | Small molecule | ||
VDR | x | CALCIPOTRIENE | psoriasis | Small molecule | ||
VDR | x | ERGOCALCIFEROL | acute coronary syndrome | Small molecule | ||
VDR | x | PARICALCITOL | chronic kidney disease | Small molecule | ||
VDR | x | CALCITRIOL | Hypocalcemia | Small molecule | ||
VDR | x | DOXERCALCIFEROL | secondary hyperparathyroidism | Small molecule | ||
VDR | x | CALCIFEDIOL | secondary hyperparathyroidism | Small molecule | ||
TYMP | x | TIPIRACIL | metastatic colorectal cancer | Small molecule | ||
TUBB6 | x | VINCRISTINE | acute lymphoblastic leukemia | Small molecule | ||
TUBB6 | x | DOCETAXEL | squamous cell carcinoma | Small molecule | ||
TUBB6 | x | PACLITAXEL | breast carcinoma | Small molecule | ||
TUBB6 | x | COLCHICINE | acute coronary syndrome | Small molecule | ||
TUBB6 | x | VINORELBINE | breast carcinoma | Small molecule | ||
TUBB6 | x | TRASTUZUMAB EMTANSINE | breast carcinoma | Antibody | ||
TUBB6 | x | BRENTUXIMAB VEDOTIN | lymphoma | Antibody | ||
TUBB6 | x | CABAZITAXEL | prostate carcinoma | Small molecule | ||
TUBB6 | x | VINBLASTINE | neoplasm | Small molecule | ||
TUBB6 | x | ERIBULIN | breast carcinoma | Small molecule | ||
TUBB6 | x | VINFLUNINE | neoplasm | Small molecule | ||
TUBB6 | x | IXABEPILONE | neoplasm | Small molecule | ||
TOP1MT | x | TOPOTECAN | acute myeloid leukemia | Small molecule | ||
RARA | x | x | TRETINOIN | acne | Small molecule | |
RARA | x | x | ADAPALENE | acne | Small molecule | |
RARA | x | x | ACITRETIN | psoriasis | Small molecule | |
RARA | x | x | ISOTRETINOIN | acne | Small molecule | |
RARA | x | x | ALITRETINOIN | Eczema | Small molecule | |
RARA | x | x | TAZAROTENE | psoriasis | Small molecule | |
RARA | x | x | ETRETINATE | psoriasis | Small molecule | |
PSMB10 | x | BORTEZOMIB | multiple myeloma; Glycogen storage disease due to acid maltase deficiency | Small molecule | ||
PSMB10 | x | IXAZOMIB CITRATE | multiple myeloma | Small molecule | ||
PSMB10 | x | CARFILZOMIB | neoplasm | Protein | ||
PDK3 | x | SODIUM DICHLOROACETATE | lactic acidosis | Small molecule | ||
IL4R | x | DUPILUMAB | Eczema | Antibody | ||
IL23A | x | x | USTEKINUMAB | psoriasis | Antibody | |
IL17RA | x | BRODALUMAB | psoriasis | Antibody | ||
IFNGR2 | x | INTERFERON GAMA-1B | relapsing-remitting multiple sclerosis | Protein | ||
IFNGR2 | x | INTERFERON GAMMA-1B | idiopathic pulmonary fibrosis | Protein | ||
HCK | x | BOSUTINIB | neoplasm | Small molecule | ||
FGR | x | x | DASATINIB | chronic myelogenous leukemia | Small molecule | |
EPHB6 | x | x | VANDETANIB | thyroid carcinoma | Small molecule | |
EPHB6 | x | x | PREDNIMUSTINE | lymphoma | Small molecule | |
CSF3R | x | x | PEGFILGRASTIM | breast carcinoma | Protein | |
CSF3R | x | x | FILGRASTIM | myocardial infarction | Protein | |
CSF3R | x | x | LIPEGFILGRASTIM | lymphoma | Small molecule | |
CD52 | ALEMTUZUMAB | diabetes mellitus | Antibody | |||
CD3D | x | x | BLINATUMOMAB | acute lymphoblastic leukemia | Antibody | |
CD3D | x | x | MUROMONAB-CD3 | immune system disease | Antibody | |
CD3D | x | x | CATUMAXOMAB | neoplasm | Antibody | |
BCR | x | PONATINIB | neoplasm | Small molecule | ||
ALOX5 | x | SULFASALAZINE | rheumatoid arthritis | Small molecule | ||
ALOX5 | x | ZILEUTON | asthma | Small molecule | ||
ALOX5 | x | MESALAMINE | ulcerative colitis | Small molecule | ||
ALOX5 | x | BALSALAZIDE | ulcerative colitis | Small molecule | ||
ALOX5 | x | OLSALAZINE | ankylosing spondylitis | Small molecule |
