Table 4 List of the Broad Institute public library of compounds associated with gene targets in CMV, EBV or HHV6 human host response based on CMAP45 analysis of contrary gene expression profiles.
Compound | Mechanism of Action | Indication | CMV Host response signature | EBV Host response signature | HHV6 Host response signature | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Compound Score | Enrichment Score | P-Value | Compound Score | Enrichment Score | P-Value | Compound Score | Enrichment Score | P-Value | |||
Quinostatin | PI3-Kinase/mTOR inhibitors | Oncology | 1.00 | −0.87 | 0.0337 | 1 | −0.94 | 0.0085 | NA | NA | NA |
Cortisone | Corticosteroid Hormone Receptor Agonists | Anti-inflammatory | 0.50 | −0.88 | 0.0285 | NA | NA | NA | NA | NA | NA |
Quinethazone | Sodium/chloride tranporter inhibitor | Antihypertension | 0.50 | −0.84 | 0.0492 | NA | NA | NA | NA | NA | NA |
Metrifonate | Cholinesterase inhibitor | 0.37 | −0.95 | 0.0054 | NA | NA | NA | NA | NA | NA | |
Cicloheximide | Protein synthesis inhibitor | Antibiotics | 0.33 | −0.99 | 0.0002 | 0.33 | −0.93 | 0.0107 | NA | NA | NA |
Anisomycin | MAP kinase activator | Neuro protection 71 | 0.33 | −0.97 | 0.0023 | 0.33 | −0.96 | 0.0038 | NA | NA | NA |
Molindone | Dopamine receptor antagonist | Neuro protection 69 | 0.33 | −0.94 | 0.0059 | NA | NA | NA | 0.33 | −0.90 | 0.0216 |
Hydroflumethiazide | Na-Cl cotransporter inhibitor | Antihypertensive | 0.33 | −0.94 | 0.0077 | NA | NA | NA | NA | NA | NA |
Pronetalol | Adrenoreceptor blocker (beta) | Neuro protection69 | 0.33 | −0.93 | 0.0089 | NA | NA | NA | NA | NA | NA |
Picotamide | Eicosenoid receptor antagonist | Anti-inflammatory | 0.33 | −0.93 | 0.0103 | NA | NA | NA | NA | NA | NA |
Mephenytoin | Sodium channel blocker | Antihypertensive | 0.33 | −0.89 | 0.0231 | NA | NA | NA | NA | NA | NA |
Dipivefrine | Adrenergic agonist | Neuro protection 69 | 0.33 | −0.87 | 0.0343 | NA | NA | NA | NA | NA | NA |
Etamsylate | Prostaglandin synthesis inhibitor | Anti-inflammatory | 0.33 | −0.85 | 0.0422 | NA | NA | NA | NA | NA | NA |
Mebeverine | Phosphodiesterase inhibitor | Neuro protection 88 | 0.33 | −0.85 | 0.045 | NA | NA | NA | NA | NA | NA |
Prasterone | Estrogen receptor (ER) agonists Androgen receptor (AR) agonists | Neuro protection 89 | 0.33 | −0.85 | 0.0467 | NA | NA | NA | NA | NA | NA |
Pirenzepine | Muscarinic M1 receptor antagonist | Neuro protection 69 | 0.30 | −0.95 | 0.0045 | NA | NA | NA | NA | NA | NA |
Calmidazolium | Calmodulin binding inhibitor | Immunosuppressant | NA | NA | NA | 1.00 | −0.9023 | 0.0193 | NA | NA | NA |
Antazoline | Histamine H1 receptor antagonist | Allergy | NA | NA | NA | 0.33 | −0.8696 | 0.0342 | NA | NA | NA |
Beta-escin | Vasoconstriction | Cardiovascular Agent [Pubchem] | NA | NA | NA | 0.33 | −0.7912 | 0.0181 | NA | NA | NA |
Betahistine | Histamine H1 receptor agonist | Anti-vertigo | NA | NA | NA | 0.33 | −0.8763 | 0.0312 | NA | NA | NA |
Cephaeline | Anti-neoplastic | Oncology | NA | NA | NA | 0.33 | −0.9537 | 0.0002 | NA | NA | NA |
Cetirizine | Histamine H1 receptor antagonist | Allergy | NA | NA | NA | 0.33 | −0.8937 | 0.023 | NA | NA | NA |
Dequalinium chloride | Anti-bacterial | Antibiotics | NA | NA | NA | 0.33 | −0.9666 | 0.0021 | NA | NA | NA |
Domperidone | Dopamine receptor D2 antagonist | Antiemetic | NA | NA | NA | 0.33 | −0.8436 | 0.0495 | NA | NA | NA |
Emetine | anti-parasitic | Anti-parasitic | NA | NA | NA | 0.33 | −0.9978 | 0 | NA | NA | NA |
Felodipine | Calcium channel (L-type) blocker | Antihypertensive | NA | NA | NA | 0.33 | −0.6897 | 0.0066 | NA | NA | NA |
Flunarizine | Sodium channel antagonist; Calmodulin binding and H1 antagonist | Severe Migraine | NA | NA | NA | 0.33 | −0.9181 | 0.0137 | NA | NA | NA |
Metergoline | Serotonin and Dopamine receptors ligand | Pychoactive (Drug Bank) | NA | NA | NA | 0.33 | −0.9576 | 0.0036 | NA | NA | NA |
Natamycin | Anti-infective agent | Anti-parasitic | NA | NA | NA | 0.33 | −0.9229 | 0.0121 | NA | NA | NA |
Pargyline | Monoamine oxidase inhibitor | Neuro protection 87 | NA | NA | NA | 0.33 | −0.937 | 0.0081 | NA | NA | NA |
Perhexiline | CPT inhibitor | Cardiovascular Agent [Pubchem] | NA | NA | NA | 0.33 | −0.8921 | 0.0238 | NA | NA | NA |
Phenyl propanolamine | Adrenoreceptor agonist (alpha) | Allergy | NA | NA | NA | 0.33 | −0.9258 | 0.0113 | NA | NA | NA |
Piribedil | Dopamine receptor agonist | Parkinson’s Treatment | NA | NA | NA | 0.33 | −0.9197 | 0.0132 | NA | NA | NA |
Pyrvinium | Anthelmintic | Anti-parasitic | NA | NA | NA | 0.33 | −0.7906 | 0.0039 | NA | NA | NA |
Saquinavir | HIV Protease inhibitor | Anti-retroviral | NA | NA | NA | 0.33 | −0.8712 | 0.0335 | NA | NA | NA |
Talampicillin | Peptidoglycan synthesis inhibitor | Antibiotics | NA | NA | NA | 0.33 | −0.8465 | 0.0476 | NA | NA | NA |
Tretinoin | Retinoid | Skin related conditions | NA | NA | NA | 0.33 | −0.4968 | 0.0017 | NA | NA | NA |
Cyclopenthiazide | Sodium Chloride Symporter Inhibitor | Antihypertensive | NA | NA | NA | NA | NA | NA | 0.33 | −0.9846 | 0.0004 |
Alcuronium chloride | Cholinergic receptor antagonist | Muscle relaxant | NA | NA | NA | NA | NA | NA | 1.00 | −0.956 | 0.0036 |
Pergolide | Dopamine receptor agonist | Pychoactive (Drug Bank) | NA | NA | NA | NA | NA | NA | 0.33 | −0.957 | 0.0036 |
Staurosporine | Protein kinase inhibitor | Oncology | NA | NA | NA | NA | NA | NA | 1.00 | −0.8538 | 0.006 |
Hemicholinium | Acetylcholine stores depletor | Neuro protection 1 | NA | NA | NA | NA | NA | NA | 0.33 | −0.9296 | 0.0094 |
Suramin sodium | Topoisomerase inhibitor | Oncology | NA | NA | NA | NA | NA | NA | 0.45 | −0.9171 | 0.013 |
Pyrantel | antihelmintic | Anti-parasitic | NA | NA | NA | NA | NA | NA | 0.33 | −0.9011 | 0.0191 |
Arachidonyl trifluoromethane | Phospholipase A2 inhibitor | Anti-inflammatory | NA | NA | NA | NA | NA | NA | 1.00 | −0.9004 | 0.0193 |
Triprolidine | Histamine H1 receptor antagonist | Allergy | NA | NA | NA | NA | NA | NA | 0.33 | −0.8889 | 0.0242 |
Ethambutol | Chelating agent | Antibiotics | NA | NA | NA | NA | NA | NA | 0.30 | −0.886 | 0.0255 |
Minaprine | 5-HT2 receptor inhibitor; Dopamine receptor agonist | Parkinson’s Treatment | NA | NA | NA | NA | NA | NA | 0.37 | −0.8763 | 0.0303 |
Nimesulide | Cyclooxygenase-2 inhibitor | Anti-inflammatory | NA | NA | NA | NA | NA | NA | 0.33 | −0.8728 | 0.0322 |
Ganciclovir | DNA synthesis inhibitor | Antibiotics | NA | NA | NA | NA | NA | NA | 0.33 | −0.8612 | 0.0382 |
Sparteine | Anti-inflammatory diuretic Anti-infective agent | Anti-inflammatory | NA | NA | NA | NA | NA | NA | 0.33 | −0.85 | 0.0446 |
Pentoxifylline | Phosphodiesterase inhibitor | Intermittent Claudication | NA | NA | NA | NA | NA | NA | 0.33 | −0.849 | 0.0454 |
