Table 2 ROC curve Analysis of Biomarkers for LolBHIGH 6 h exposed mice (all brain regions) (Supporting information is in Supplementary Data Tables S1S4).

From: Tremorgenic effects and functional metabolomics analysis of lolitrem B and its biosynthetic intermediates

Metabolite

All Brain Regions: ControlVEH vs LolBHIGH

AUCs

Sensitivity (%)

Specificity (%)

95% Confidence Interval

T-tests

KM Cluster

Leucine

0.78

70%

70%

0.65–0.90

3.7E-4

5.0

Methionine

0.74

80%

70%

0.62–0.87

4.1E-3

1.0

Isoleucine

0.74

60%

80%

0.61–0.86

9.0E-4

5.0

Tyrosine

0.74

80%

70%

0.61–0.86

1.3E-3

1.0

Valine

0.70

60%

80%

0.57–0.83

1.8E-3

2.0