Figure 3

Distribution of mean site-specific CpG methylation levels by genomic region for CpG sites identified as hypermethylated in IDH^mut versus IDH^wt tumors. The density of probes at each CpG site (y-axis) is plotted versus methylation β-values (x-axis). Islands are genomic areas with relatively high CpG content flanked by shores (up to 2 kilobases) and shelves (2–4 kilobases from island). North shore and shelf represent 5′ end, and south shore and shelf represent 3′ end. The open sea represents the rest of the genome. Gold lines represent CpG methylation in IDH^wt tumors and blue lines represent CpG methylation in IDH^mut tumors.