Figure 4

Differential methylation and transcription signatures between IDH^mut and IDH^wt groups within each cancer type. (A) Methylation heatmap of differences in CpG site beta values between IDH^mut and IDH^wt tumors for all genes demonstrating statistically significant hypermethylation in at least one tumor type. (B) Venn diagram representing the overlap of hypermethylated genes of IDH^mut cancers compared with IDH^wt control. (C) Gene expression heatmap of log fold change (FC) gene expression between IDH^mut and IDH^wt tumors for all genes demonstrating statistically significant differential expression in at least one tumor type. (D) Venn diagram representing the overlap of differentially expressed genes of IDH^mut cancers compared with IDH^wt control.