Figure 3 | Scientific Reports

Figure 3

From: The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson’s disease patients

Figure 3

Effect of MPTP-induced striatal dopamine depletion and L-DOPA supplementation on free amino acids levels in the monkey medial frontal gyrus. (a) Dopamine (expressed as pg/mg of fresh tissue), and free amino acids (b) D-aspartate, (c) L-aspartate (d) D-serine, (e) L-serine and (f) L-glutamate (expressed as nmol/mg protein) were measured by HPLC in untreated (control), MPTP- and (MPTP + L-DOPA)-treated monkeys (n = 5 monkeys/treatment). All free amino acids were detected in a single run. **p < 0.01, compared to control group; ##p < 0.01, compared to MPTP-treated group (Fisher’s post-hoc). Dots represent the single subjects’ values while bars illustrate the means ± SEM.

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