Figure 5
Ultrastructural effects of omeprazole (B–D), metronidazole (E,F), and nitazoxanide (G,H) on Giardia trophozoites. Control trophozoites were incubated with 0.05% DMSO (A). The ventral disk (vd), one of the two nuclei (n), and flagella (transversally cut) (f) are visible. Cells treated with omeprazole at 0.072 (B), 0.144 (C), and 1 μM (D). Cells treated with metronidazole at 1.24 (E) and 2.48 μM (F). Cells treated with nitazoxanide at 0.016 (G) and 0.032 μM (H). Asterisks show drug-induced vesicles. Arrows show lamellar structures. All treatments lasted 24 h independent of the compound used. Bar, 0.5 μm.
