Figure 6

Transcriptional profile of the SSG_R and SSG_S lines in L. braziliensis and L. panamensis. (A) Venn diagram showing transcripts down- and up-regulated more than 2-fold in the resistant lines regarding the expression levels found in the parental sensitive line. The number of transcripts having significantly altered levels (up and down regulated) and the number of transcripts with DE when both species were compared (middle of each diagram) (B,C) Differentially expressed transcripts between the experimental conditions. B (L. braziliensis). C (L. panamensis). The graphic in the middle represents the MA plot constructed based on the DESeq2 results. Red points indicate significance at a 10% adjusted p-value, up-regulation and down-regulation respectively. Grey triangles indicate transcripts that showed no change. The lower figures present the results of the Gene Ontology enrichment analyses for biological process of up (left) and down (right) regulated transcripts. The transcripts included had an expression value higher than 2-fold change in both comparisons. The number of transcripts with a GO term is indicated in the corresponding pie slice.