Table 1 Putative FNU1 proteins and their homology to published sequences.

ORF1

1..1659

553

Gifsy-2 prophage tail fiber protein, partial [Salmonella enterica subsp. enterica serovar Newport str. SHSN010]

55

9

1.00E − 06

ORF2

1770..2267

166

No significant similarity found

ORF3

2264..2464

67

No significant similarity found

ORF4

2457..2855

133

Hybrid sensor histidine kinase/response regulator [Pedobacter heparinus]

47

28

9.40E + 00

ORF5

2857..3399

181

No significant similarity found

ORF6

3396..4223

276

Nucleotidyltransferase domain-containing protein [Balneola sp.]

35

92

2.00E − 29

ORF7

4217..4948

244

Hypothetical protein [Bacillus sp.]

35

97

2.00E − 35

ORF8

4950..5366

139

ComF family protein [Yoonia litorea]

31

38

8.30E − 01

ORF9

5575..5796

74

rfaE bifunctional protein [Desulfurobacterium thermolithotrophum DSM 11699]

27

60

7.60E − 01

ORF10

5884..6558

225

Hypothetical protein [Staphylococcus xylosus]

40

91

2.00E − 41

ORF11

6577..7395

273

Antirepressor [Fusobacterium necrophorum]

39

97

7.00E − 44

ORF12

8220..8831

204

Hypothetical protein [Olleya sp. VCSM12]

30

58

8.40E + 00

ORF13

8835..9557

241

No significant similarity found

ORF14

9557..11392

612

Hypothetical protein DRJ01_10315, partial [Bacteroidetes bacterium]

28

77

5.00E − 41

ORF15

11402..12949

516

Hypothetical protein DRJ01_10320 [Bacteroidetes bacterium]

29

96

1.00E − 41

ORF16

13878..14297

140

Methyl-CpG-binding domain-containing protein 9 [Cicer arietinum]

27

73

7.40E + 00

ORF17

14397..15473

359

No significant similarity found

ORF18

15775..16071

99

No significant similarity found

ORF19

16073..16444

124

Myosin-IB-like [Plutella xylostella]

31

50

8.50E + 00

ORF20

16437..16991

185

Hypothetical protein UU59_C0024G0011 [candidate division WWE3 bacterium GW2011_GWE1_41_27]

26

89

1.00E + 00

ORF21

16988..17623

212

No significant similarity found

ORF22

17665..18798

378

Type I secretion system permease/ATPase [Mesorhizobium sp. WSM4313]

44

16

3.30E + 00

ORF23

18866..19642

259

No significant similarity found

ORF24

19639..20283

215

No significant similarity found

ORF25

20293..26217

1975

Phage tail tape measure protein, TP901 family, core region [Cetobacterium ceti]

24

26

4.00E − 20

ORF26

26279..27295

339

Hypothetical protein [Brevibacillus fluminis]

43

12

7.90E + 00

ORF27

27390..28244

285

Hypothetical protein [Fusobacterium periodonticum]

42

70

4.00E − 31

ORF28

28300..28674

125

No significant similarity found

ORF29

29187..32576

1130

DUF1983 domain-containing protein [Rhizobium subbaraonis]

26

13

3.00E − 05

ORF30

33217..34371

385

Transposase [Fusobacterium sp. CM1]

84

97

0.00E + 00

ORF31

34498..35637

380

Hypothetical protein [Cetobacterium sp. ZWU0022]

41

43

1.00E − 26

ORF32

35640..36641

334

No significant similarity found

ORF33

36653..37438

262

Hypothetical protein AKJ51_02780 [candidate divison MSBL1 archaeon SCGC-AAA382A20]

25

29

2.70E + 00

ORF34

37551..38327

259

ATP/GTP-binding protein [Streptococcus parasanguinis]

37

96

5.00E − 26

ORF35

38303..38713

137

No significant similarity found

ORF36

39575..39889

105

Anaerobic ribonucleoside-triphosphate reductase [Fusobacterium perfoetens]

44

90

3.00E − 18

ORF37

41026..41247

74

No significant similarity found

ORF38

(41608..41883)

92

No significant similarity found

ORF39

(42013..42279)

89

Homoserine kinase [Fusobacterium sp. CM1]

47

47

8.60E + 00

ORF40

(42455..42775)

107

No significant similarity found

ORF41

(43304..43540)

79

No significant similarity found

ORF42

(44438..44680)

81

Serine–tRNA ligase [Candidatus Daviesbacteria bacterium RIFCSPHIGHO2_01_FULL_37_27]

40

53

7.40E + 00

ORF43

(44816..45196)

127

Hypothetical protein [Lactobacillus reuteri]

48

52

2.00E − 11

ORF44

(45315..45611)

99

Hypothetical protein [uncultured Mediterranean phage uvMED]

42

65

9.00E − 03

ORF45

(46128..46544)

139

No significant similarity found

ORF46

(46574..46885)

104

No significant similarity found

ORF47

(46903..47127)

75

Hypothetical protein J132_07476 [Termitomyces sp. J132]

37

65

6.20E + 00

ORF48

(47138..47506)

123

Alkaline phosphatase [Stackebrandtia nassauensis]

23

75

9.20E + 00

ORF49

(47521..47745)

75

No significant similarity found

ORF50

(48158..48322)

54

No significant similarity found

ORF51

(48727..49209)

161

Anaerobic ribonucleoside-triphosphate reductase activating protein [Fusobacterium sp.]

51

91

2.00E − 50

ORF52

(49458..49658)

67

No significant similarity found.

ORF53

(49670..49996)

108

Hypothetical protein DV735_g31 [Chaetothyriales sp. CBS 134920]

36

71

7.50E − 01

ORF54

(50006..50467)

154

No significant similarity found

ORF55

(50467..50955)

163

No significant similarity found

ORF56

(51137..52471)

445

Anaerobic ribonucleoside-triphosphate reductase [Fusobacterium perfoetens]

53

98

3.00E − 167

ORF57

(52800..53834)

345

GIY-YIG nuclease family protein [Clostridioides difficile]

42

55

1.00E − 35

ORF58

(53905..54813)

303

Anaerobic ribonucleoside-triphosphate reductase [Fusobacterium varium]

46

98

1.00E − 71

ORF59

(54800.55060)

87

Hypothetical protein OFPII_09960 [Osedax symbiont Rs1]

38

51

8.30E − 01

ORF60

(55064..55387)

108

No significant similarity found

ORF61

(55384..55851)

156

No significant similarity found

ORF62

(56004..56456)

151

No significant similarity found

ORF63

(56485..56724)

80

Mitochondrial carrier homolog 2 [Drosophila arizonae]

40

53

8.50E + 00

ORF64

(56733..56978)

82

Glycosyltransferase [Algoriphagus resistens]

36

59

8.10E − 01

ORF65

(56985..57296)

104

No significant similarity found

ORF66

(57298..57597)

100

No significant similarity found

ORF67

(58609..58989)

127

Outer membrane protein assembly factor BamA [Sutterella parvirubra]

27

62

3.40E + 00

ORF68

(59003..59752)

250

Hypothetical protein [Fusobacterium nucleatum]

33

31

1.70E − 02

ORF69

(59754..60326)

191

Hypothetical protein [Fusobacterium periodonticum]

37

32

8.60E − 01

ORF70

(60323..60697)

125

No significant similarity found

ORF71

(60676..60894)

73

ATP-dependent DNA ligase [Rhizophagus irregularis]

37

67

5.90E + 00

ORF72

(60916..61179)

88

Hypothetical protein [Desulfobacula toluolica]

26

70

5.60E − 01

ORF73

(61184..61369)

62

No significant similarity found

ORF74

(61359..61799)

147

Hypothetical protein SAMN05444672_10818 [Bacillus sp. OK838]

50

28

2.40E + 00

ORF75

(61796..62185)

62

No significant similarity found

ORF76

(62176..62544)

123

No significant similarity found

ORF77

(62560..63000)

147

No significant similarity found

ORF78

(63013..63480)

156

Molecular chaperone DnaJ [Paenibacillus sp. Soil724D2]

32

91

2.00E − 19

ORF79

(63778..64101)

108

DUF1874 domain-containing protein [Defluviitalea phaphyphila]

57

97

2.00E − 31

ORF80

(64133..64306)

58

Hypothetical protein HMPREF1127_1046 [Fusobacterium necrophorum subsp. funduliforme Fnf 1007]

49

82

1.00E − 07

ORF81

(64450..64671)

74

DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family [Crenotalea thermophila]

45

56

7.10E + 00

ORF82

(64738..65517)

260

Radical SAM protein [Clostridium botulinum]

49

94

5.00E − 79

ORF83

(65598..68396)

933

Hypothetical protein [Fusobacterium necrophorum]

36

6

8.80E − 01

ORF84

(68490..68984)

165

Hypothetical protein [Fusobacterium hwasookii]

41

88

6.00E − 32

ORF85

(68984..69172)

63

Hypothetical protein [Fusobacterium periodonticum]

68

98

3.00E − 22

ORF86

(69291..69605)

105

Hypothetical protein YYE_03786 [Plasmodium vinckei vinckei]

36

62

5.20E − 01

ORF87

(69589..69942)

118

Na + /H + antiporter [Porphyromonas sp. oral taxon 279]

26

73

3.40E + 00

ORF88

(69911..70651)

247

No significant similarity found

ORF89

(70663..71040)

126

Hypothetical protein [Lactobacillus sp. CBA3605]

33

41

5.30E + 00

ORF90

(71042..71473)

144

Guanylate-binding protein 6-like [Eptesicus fuscus]

37

48

2.90E − 01

ORF91

(71466..71660)

65

Hypothetical protein [Rhodopirellula sp. SWK7]

43

64

1.40E + 00

ORF92

(71647..71922)

92

Tyrosine recombinase XerC [Chloracidobacterium thermophilum]

41

47

8.60E + 00

ORF93

(72047..72946)

300

No significant similarity found

ORF94

(73058..73651)

198

Hypothetical protein CTER_0441 [Ruminiclostridium cellobioparum subsp. termitidis CT1112]

33

43

5.50E + 00

ORF95

(73706..76168)

821

Polymerase protein [candidate division WWE3 bacterium GW2011_GWC2_44_9]

30

37

3.00E − 28

ORF96

(76155..77018)

288

Guanylate kinase [Emticicia sp. MM]

39

62

6.00E − 24

ORF97

(77327..78076)

250

MerR family transcriptional regulator [Bacillus sp. EB01]

23

54

1.50E + 00

ORF98

(78095..78961)

289

Fic family protein [Fusobacterium nucleatum]

38

66

8.00E − 30

ORF99

(78937..79356)

140

Hypothetical protein BpsS36_00041 [Bacillus phage vB_BpsS-36]

42

94

6.00E − 18

ORF100

(79396..79920)

175

Siphovirus Gp157 family protein [Fusobacterium nucleatum]

51

89

3.00E − 39

ORF101

(79933..80406)

158

No significant similarity found

ORF102

(80372..80731)

120

Hypothetical protein TBLA_0I01080 [Tetrapisispora blattae CBS 6284]

31

66

9.50E + 00

ORF103

(80744..81175)

144

O-acetyl-ADP-ribose deacetylase 1-like [Branchiostoma belcheri]

44

98

3.00E − 36

ORF104

(81177..81731)

185

Hypothetical protein [Clostridium botulinum]

34

96

1.00E − 20

ORF105

(81819..82436)

206

Hypothetical protein [Fusobacterium nucleatum]

32

83

2.00E − 13

ORF106

(82601..83236)

212

Hypothetical protein [Clostridium sp. 12(A)]

49

85

7.00E − 53

ORF107

(83330..84430)

367

DNA cytosine methyltransferase [Methanobrevibacter ruminantium]

31

98

9.00E − 57

ORF108

(84452..84640)

63

No significant similarity found

ORF109

(84691..86247)

519

Hypothetical protein FUSO4_11650 [Fusobacterium necrophorum DJ-1]

49

97

7.00E − 166

ORF110

(86400..86783)

128

Isovaleryl-CoA dehydrogenase [Erythrobacter gangjinensis]

40

50

1.30E − 01

ORF111

(86773..87030)

86

Hypothetical protein ABS80_03590 [Pseudonocardia sp. SCN 72–51]

33

60

6.20E − 01

ORF112

(87053..88336)

428

ATP dependent DNA ligase domain protein [Clostridioides difficile]

37

97

2.00E − 67

ORF113

(88329..88946)

206

VP1 protein, partial [Coxsackievirus A16]

33

23

1.70E + 00

ORF114

(88947..89186)

80

No significant similarity found

ORF115

(89161..89643)

161

DNA repair protein MmcB-related protein [Fusobacterium]

30

88

1.00E − 15

ORF116

(89640..89858)

73

No significant similarity found

ORF117

(89842..90486)

215

Hypothetical protein [Fusobacterium necrophorum]

45

80

1.00E − 41

ORF118

(90575..91204)

210

Hypothetical protein [Adhaeribacter aquaticus]

25

59

4.30E + 00

ORF119

(91309..92733)

475

Hypothetical protein [Ralstonia phage RSP15]

27

67

2.00E − 25

ORF120

(92743..93252)

170

dUTP diphosphatase [Clostridium bartlettii CAG:1329]

41

99

5.00E − 28

ORF121

(93249..94526)

426

Hypothetical protein [Bacillus endophyticus]

24

73

8.00E − 26

ORF122

(94529..95317)

263

ORF6N domain-containing protein [Fusobacterium nucleatum]

43

77

5.00E − 44

ORF123

(95417..96418)

334

DNA primase (bacterial type) [Chlamydia trachomatis]

39

50

1.00E − 18

ORF124

(96431..97912)

494

DNA helicase [Clostridium botulinum]

29

54

4.00E − 25

ORF125

(97909..98334)

142

epsC Polysaccharide biosynthesis protein, protein-tyrosine-phosphatase [Lactococcus lactis subsp. lactis]

33

52

1.90E + 00

ORF126

(98404..99702)

432

No significant similarity found

ORF127

(99709..100146)

146

Phage antirepressor [Clostridium innocuum]

41

79

4.00E − 22

ORF128

(100272..100976)

235

ATP-binding protein [Peptoniphilus obesi]

37

91

2.00E − 38

ORF129

(100986..101510)

175

Hypothetical protein DLH72_04485 [Candidatus Gracilibacteria bacterium]

36

96

4.00E − 17

ORF130

(101497..101679)

61

No significant similarity found

ORF131

(101885..102676)

264

DNA adenine methylase [Ruminococcus albus]

39

92

3.00E − 41

ORF132

(102741..103346)

202

Ribonuclease HI [Fusobacterium russii]

53

99

1.00E − 63

ORF133

(103346..103561)

72

No significant similarity found

ORF134

(103545..103769)

75

Hypothetical protein K457DRAFT_16159 [Mortierella elongata AG-77]

40

46

6.00E + 00

ORF135

(103871..104125)

85

No significant similarity found

ORF136

(104118..104633)

172

Hypothetical protein [Selenomonas bovis]

52

25

5.00E − 04

ORF137

(104773..104997)

75

Multidrug efflux RND transporter permease subunit [Motiliproteus coralliicola]

30

98

5.50E + 00

ORF138

(104997..105212)

72

Peptide ABC transporter substrate-binding protein [Vibrio gangliei]

38

61

4.80E + 00

ORF139

(105199..105858)

220

Transcriptional regulator, TetR family [Clostridium sp. MSTE9]

30

37

1.60E + 00

ORF140

(105871..106029)

53

Hypothetical protein L915_04856, partial [Phytophthora parasitica]

46

49

2.60E + 00

ORF141

(106133..106942)

270

Prohibitin family protein [Fusobacterium periodonticum]

77

99

3.00E − 150

ORF142

(106942..107316)

125

Hypothetical protein [Fusobacterium necrophorum]

48

37

1.40E + 00

ORF143

(107317..107580)

88

Type II toxin-antitoxin system HipA family toxin [Prevotella sp. ICM33]

29

75

5.20E + 00

ORF144

(107584..108336)

251

Hypothetical protein [Corynebacterium matruchotii]

52

98

2.00E − 89

ORF145

(108336..108842)

169

Hypothetical protein [Fusobacterium nucleatum]

50

33

1.00E − 06

ORF146

(108939..109391)

151

Furin-1 precursor [Schistosoma japonicum]

32

53

9.00E − 02

ORF147

(109396..109905)

170

No significant similarity found

ORF148

(109906..110742)

279

Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase [Agrococcus casei]

29

97

3.00E − 13

ORF149

(110730..111284)

185

Hypothetical protein A2Y22_00670 [Clostridiales bacterium GWD2_32_59]

27

74

5.00E + 00

ORF150

(111332..111955)

208

TPA: tRNA (adenine-N(6)-)-methyltransferase [Candidatus Gastranaerophilales bacterium HUM_13]

39

92

3.00E − 40

ORF151

(112023..114062)

680

AAA family ATPase [Pseudodesulfovibrio profundus]

28

75

4.00E − 29

ORF152

(114111..115580)

490

Hypothetical protein [Clostridium botulinum]

37

85

1.00E − 69

ORF153

115966..116148

61

No significant similarity found

ORF154

116254..116772

173

No significant similarity found

ORF155

116783..117202

140

No significant similarity found

ORF156

117202..117636

145

Heparinase [Paenibacillus macerans]

33

37

4.20E + 00

ORF157

117630..117812

61

No significant similarity found

ORF158

117915..118142

76

No significant similarity found

ORF159

118123..119262

380

Hypothetical protein [Fusobacterium mortiferum]

68

31

4.00E − 40

ORF160

119268..119579

104

Glycosyltransferase [Kingella kingae]

35

62

7.00E + 00

ORF161

119675..119983

103

Hypothetical protein [Streptococcus sobrinus]

35

86

5.00E − 15

ORF162

119997..120386

130

Hypothetical protein [Streptococcus oralis]

32

46

3.20E − 02

ORF163

120534..120965

144

Hypothetical protein [Fusobacterium periodonticum]

33

84

3.00E − 10

ORF164

120975..121694

240

No significant similarity found

ORF165

121708..122073

122

TonB-dependent receptor [Mucilaginibacter sp. OK098]

31

87

3.70E + 00

ORF166

122070..124286

739

Metallophosphoesterase [Leptotrichia hofstadii]

49

99

0.00E + 00

ORF167

124339..124518

60

No significant similarity found

ORF168

125623..125841

73

No significant similarity found

ORF169

125880..126119

80

Glutaredoxin [Fusobacterium nucleatum subsp. nucleatum]

56

78

8.00E − 17

ORF170

126477..126656

60

No significant similarity found

ORF171

126614..126901

96

HU family DNA-binding protein [Neisseria weaveri]

44

93

5.00E − 17

ORF172

127245..128036

264

ORF6N domain-containing protein [Fusobacterium necrophorum]

73

46

3.00E − 58

ORF173

128097..128273

59

No significant similarity found

ORF174

128354..129103

250

Hypothetical protein CANCADRAFT_31211 [Tortispora caseinolytica NRRL Y-17796]

33

23

9.00E + 00

ORF175

129197..129547

117

DUF1353 domain-containing protein [Fusobacterium necrophorum]

47

76

6.00E − 21

ORF176

129564..129980

139

Hypothetical protein [Fusobacterium necrophorum]

39

90

2.00E − 23

ORF177

129980..130537

186

N-acetylmuramoyl-L-alanine amidase [Fusobacterium necrophorum]

44

95

1.00E − 36

ORF178

130553..130858

102

Hypothetical protein [Aeromonas enteropelogenes]

40

50

1.40E + 00