Figure 4
From: Effect of Leptin Deficiency on the Skeletal Response to Hindlimb Unloading in Adult Male Mice
Effects of genotype and hindlimb unloading (HU) on cortical bone microarchitecture in the femur diaphysis in WT and ob/ob mice. Shown are (a) cross-sectional volume, (b) cortical volume, (c) marrow volume, (d) cortical thickness, and (e) polar moment of inertia (IPolar). Statistical analysis: Two-way ANOVA. P-values for main effects of leptin status (genotype) and skeletal loading status (HU) significant at P ≤ 0.05. Significant (P ≤ 0.05) genotype x HU interactions were not detected with treatment for any of the endpoints evaluated. Mean ± SEM; N = 10/group.
