Figure 5
From: Effect of Leptin Deficiency on the Skeletal Response to Hindlimb Unloading in Adult Male Mice
Effects of genotype and hindlimb unloading (HU) on cancellous bone microarchitecture in the distal femur metaphysis in WT and ob/ob mice. Shown are (a) cancellous bone volume fraction, (b) connectivity density, (c) structure model index, (d) trabecular number, (e) trabecular thickness, and (f) trabecular spacing. Statistical analysis: Two-way ANOVA. P-values for main effects of leptin status (genotype) and skeletal loading status (HU) significant at P ≤ 0.05. Significant (P ≤ 0.05) genotype x HU interactions were not detected with treatment for any of the endpoints evaluated. Mean ± SEM; N = 10/group.
