Table 1 Demographic, clinical data and laboratory characterization of the individuals enrolled for this study.

Number

40

35

40

28

Age, years [median; IQR]

75.00 [72.75–78.00]

75.00 [71.00–79.00]

79.00 [73.25–80.75]

74.00 [67.25–80.00]

ns^b

Gender (M:F)

16:24

14:21

18:22

18:10

ns^c

MMSE score [median; IQR]

nd

25.7 [24.00–27.08]

20.0 [16.88–22.60]

24.7* [22.58–25.86]

p < 0.0001^b

Y&H score [median; IQR]

nd

nd

nd

2.5 [2.0–3.0]

APOE Ɛ4 Ɛ4-/Ɛ4- (%)

80.0

62.9

47.5

75.0

p = 0.01^c

Ɛ4-/Ɛ4+

15.0

34.3

45.0

21.4

p = 0.01^c

Ɛ4 + /Ɛ4+

5.0

2.9

7.5

3.6

ns

APOE Ɛ4 carriers^a, %

20.0

37.1

52.5

24.00

p = 0.0053^c

miR-223–3p, fold expression [median; IQR]

0.97 [0.59–1.72]

0.31 [0.19–0.85]

0.21 [0.09–0.59]

29.30 [12.43–133.25]

p < 0.0001^b

Caspase-1, pg/ml [mean ± SEM]

77.20 [9.79]

137.76 [16.32]

102.37 [9.24]

263.52 [20.17]

p < 0.0001^b