Table 1 Quantitative heterogeneity analysis of the analyzed hepatic non-CYP abundance data in liver microsomes. FE, RE and df represent fixed effect, random effect and degrees of freedom, respectively. QF and QR are coefficients of heterogeneity of FE and RE models, and H2 and I2 (%) are measures of heterogeneity. *represents the scenario where QF < df leading to an outcome of the RE model similar to the FE model.
Enzyme | df | FE model | RE model | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
QF | H2 | I2 (%) | P-value | Statistical Heterogeneity | QR | H2 | I2 (%) | P-value | Statistical Heterogeneity | ||
UGT1A1 | 8 | 8.14 | 1.02 | 1.74 | 0.42 | Low | 7.92 | 0.99 | 0.00 | 0.44 | None |
UGT1A3* | 5 | 2.56 | 0.51 | 0.00 | 0.77 | None | 2.56 | 0.51 | 0.00 | 0.77 | None |
UGT1A4 | 5 | 24.66 | 4.93 | 79.73 | 0.00016 | High | 3.23 | 0.65 | 0.00 | 0.66 | None |
UGT1A6 | 6 | 8.53 | 1.42 | 29.67 | 0.20 | Low | 7.50 | 1.25 | 19.97 | 0.28 | Low |
UGT1A9* | 6 | 3.99 | 0.67 | 0.00 | 0.68 | None | 3.99 | 0.67 | 0.00 | 0.68 | None |
UGT2B4* | 3 | 2.71 | 0.90 | 0.00 | 0.44 | None | 2.71 | 0.90 | 0.00 | 0.44 | None |
UGT2B7 | 6 | 31.24 | 5.21 | 80.79 | 0.000023 | High | 6.87 | 1.14 | 12.63 | 0.33 | Low |
UGT2B10 | 2 | 3.89 | 1.95 | 48.65 | 0.14 | Medium | 3.49 | 1.75 | 42.77 | 0.17 | Medium |
UGT2B15 | 5 | 6.61 | 1.32 | 24.33 | 0.25 | Low | 5.41 | 1.08 | 7.52 | 0.37 | Low |
UGT2B17* | 3 | 1.27 | 0.42 | 0.00 | 0.74 | None | 1.27 | 0.42 | 0.00 | 0.74 | None |
CES1 | 1 | 2.41 | 2.41 | 58.45 | 0.12 | Medium | 1.00 | 1.00 | 0.00 | 0.32 | None |
FMO3* | 2 | 1.27 | 0.63 | 0.00 | 0.53 | None | 1.27 | 0.63 | 0.00 | 0.53 | None |
FMO5* | 1 | 0.18 | 0.18 | 0.00 | 0.67 | None | 0.18 | 0.18 | 0.00 | 0.67 | None |
