Table 2 Quantitative information based on pre-analyzed hepatic non-CYP abundance data in liver microsomes. %CV, CI, and k represent % coefficient of variation, confidence interval and number of studies, respectively.

From: A repository of protein abundance data of drug metabolizing enzymes and transporters for applications in physiologically based pharmacokinetic (PBPK) modelling and simulation

Enzymes

Method type

Weighted mean (pmol/mg protein)

Weighted %CV

Weighted lower 95% CI

Weighted higher 95% CI

k

UGT1A1

I

35.97

72.36

23.54

54.97

9

II

102.97

20.64

62.69

III

62.78

24.68

52.42

UGT1A3

I

25.01

154.67

10.33

60.56

6

II

238.29

8.30

75.33

III

78.45

14.37

43.53

UGT1A4

I

46.77

36.96

35.12

62.27

6

II

55.55

30.88

70.82

III

40.92

34.14

64.08

UGT1A6

I

29.71

132.67

14.08

62.67

7

II

169.39

12.55

70.32

III

50.58

20.86

42.31

UGT1A9

I

27.38

41.72

20.35

36.84

7

II

66.76

17.46

42.93

III

45.27

19.89

37.70

UGT2B4

I

49.43

44.90

32.48

75.22

4

II

65.21

27.58

88.58

III

39.24

34.11

71.62

UGT2B7

I

75.21

55.48

51.24

110.40

7

II

69.69

47.19

119.87

III

37.38

57.54

98.32

UGT2B10

I

14.72

142.73

4.47

48.51

3

II

166.74

3.99

54.28

III

74.75

6.93

31.28

UGT2B15

I

41.50

52.90

27.89

61.75

6

II

71.75

24.78

69.50

III

41.75

30.11

57.19

UGT2B17

I

5.84

198.79

1.69

20.19

4

II

324.38

1.26

27.05

III

138.85

2.12

16.14

CES1

I

1252.93

45.92

683.36

2297.24

2

II

69.68

523.92

2996.31

III

43.74

355.23

4419.19

FMO3

I

29.33

21.58

23.03

37.34

3

II

58.81

15.83

54.34

III

53.71

16.59

51.84

FMO5

I

24.63

15.10

20.00

30.32

2

II

54.98

12.08

50.21

III

55.08

12.07

50.27

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