Table 2 In vitro stability of 99mTc-labeled G3 variants. Samples were incubated with 5000-fold molar excess of histidine or in PBS. Experiments were performed in duplicates.
Conjugate | 1 h | 3 h | ||
|---|---|---|---|---|
PBS | 5000x histidine | PBS | 5000x histidine | |
[99mTc]Tc(CO)3-H6-G3 | 99 ± 0 | 99 ± 0 | 98 ± 0 | 99 ± 0 |
[99mTc]Tc(CO)3-G3-H6 | 99 ± 0 | 99 ± 0 | 99 ± 0 | 99 ± 0 |
[99mTc]Tc(CO)3-(HE)3-G3 | 99 ± 0 | 98 ± 0 | 98 ± 0 | 97 ± 1 |
[99mTc]Tc(CO)3-G3-(HE)3 | 98 ± 0 | 98 ± 0 | 97 ± 0 | 97 ± 0 |
