Table 4 Comparative biodistribution of ^99mTc-labeled G3 variants in BALB/C nu/nu mice bearing SKOV3 xenografts at 4 and 24 h pi.

Blood

0.19 ± 0.06^c

0.14 ± 0.03^e

0.18 ± 0.03^f

0.36 ± 0.07

Salivary glands

1.9 ± 0.2^c

1.5 ± 0.2

0.7 ± 0.2^b,d

1. 1 ± 0.3

Lung

0.5 ± 0.1^a

0.7 ± 0.1

0.34 ± 0.02^b,d,f

0.6 ± 0.1

Liver

5.5 ± 0.3^c

4.2 ± 0.9

1.8 ± 0.1^b,d,f

3.1 ± 0.7

Spleen

0.9 ± 0.1^a

1.1 ± 0.1

0.47 ± 0.04^b,d,f

1.0 ± 0.1

Stomach

0.8 ± 0.1

0.8 ± 0.2

0.4 ± 0.1^b,d

0.7 ± 0.1

Kidney

297 ± 16^a,c

220 ± 30

237 ± 30

211 ± 41

Tumor

9 ± 3

8 ± 2

9 ± 1

7 ± 1

Muscle

0.21 ± 0.03

0.3 ± 0.1

0.11 ± 0.01^b,d,f

0.23 ± 0.04

Bone

0.9 ± 0.1

0.9 ± 0.3

0.4 ± 0.1^b,d

0.7 ± 0.2

Blood

0.07 ± 0.01^c

0.08 ± 0.01^e

0.09 ± 0.01^f

0.15 ± 0.01

Salivary glands

1.0 ± 0.3

1.5 ± 0.2^e

0.4 ± 0.1^d

0.8 ± 0.2

Lung

0.3 ± 0.1

0.7 ± 0.1

0.3 ± 0.1

0.4 ± 0.1

Liver

3.6 ± 0.4^a,c

4.6 ± 0.4

1.2 ± 0.2^b,d,f

2.6 ± 0.1

Spleen

0.9 ± 0.4

1.1 ± 0.1

0.4 ± 0.1^b,d,f

0.9 ± 0.1

Stomach

0.4 ± 0.1

0.9 ± 0.1

0.22 ± 0.04^b,d,f

0.40 ± 0.03

Kidney

177 ± 25

212 ± 31

134 ± 16^b

144 ± 7

Tumor

8 ± 2^c

9 ± 1

7 ± 2

5 ± 1

Muscle

0.16 ± 0.02

0.31 ± 0.04

0.08 ± 0.02^d,f

0.20 ± 0.04

Bone

0.5 ± 0.1^c

1.0 ± 0.3

0.3 ± 0.1^d,f

0.8 ± 0.1