Figure 5
Mice showing a ketamine-induced increase in social interaction behavior exhibit a restoration of vmPFC 20–40 Hz events. (A) Changes in the SI ratios of stress-susceptible mice by saline (left, n = 8 mice) or ketamine (right, n = 13 mice) administration. Each line shows each mouse. Six mice (magenta) showed marked increases in SI ratios after ketamine administration (termed “restored”), whereas the other seven mice showed no changes in SI ratio (termed “non-restored”). (B) (Left) Increases in vmPFC 20–40 Hz event rates in the restored mice (n = 9 electrodes from 4 mice). (Right) No significant changes in vmPFC 20–40 Hz event rates were observed in the 5 non-restored mice that showed no changes in SI ratios after ketamine treatment (n = 10 electrodes from 5 mice). *P < 0.05, paired t-test.
