Figure 2

Fabry rats develop lenticular opacities. (A) Shown are representative slit lamp images of rat lenses at 12–15 weeks of age. The lens opacity scoring rubric is shown in the green box, and assigned scores are shown below the representative images. White arrows indicate opacities. (B) Lens opacity scores are plotted from 6 WT males, 7 KO males, 9 WT females, 9 heterozygous (HET) females, and 9 KO females at 12–15 weeks of age. Male median scores were compared using a Mann-Whitney test, and female median scores were compared using a Kruskal-Wallis test and Dunn’s multiple comparison test; ns = not significant (P ≥ 0.05), **P < 0.01, and ****P < 0.0001. Representative slit lamp images of rat lenses at (C) 9 weeks (n = 2 WT males, n = 2 KO males) and (D) 76 weeks (n = 2 WT males, n = 3 KO males) are shown.