Figure 5
From: Rats deficient in α-galactosidase A develop ocular manifestations of Fabry disease
α-galactosyl glycoconjugates are detected in Fabry rat keratocytes, lens fibers, and retinal vessel endothelial cells. Rat eyes were fixed with 1% formalin/1.25% glutaraldehyde, and paraffin-embedded sections were stained with isolectin B4, a lectin that specifically binds to glycoconjugates with terminal α-galactose. Hematoxylin was used as a counterstain. Images are representative of 3 WT and 3 KO male rats at 80 weeks, and the scale bars represent 50 µm. Arrows indicate keratocytes, and asterisks indicate retinal vessels. The insets (solid boxes) show magnified views of the selected regions enclosed in dashed boxes. Abbreviations: epithelium (epi), endothelium (endo).
