Table 1 Episodes of arrhythmias and ECG parameters of male Sprague-Dawley Conventional and SPF rats after 7 days acclimation in the laboratory prior to experimentation.

From: Conventional and Specific-Pathogen Free Rats Respond Differently to Anesthesia and Surgical Trauma

Parameter

Conventional

(n = 20)

SPF

(n = 20)

p value

Total Arrhythmias

0 ± 0

21.55 ± 5.91

(0–87)

 < 0.001

PVCs

0 ± 0

16.15 ± 4.48

(0–74)

 < 0.001

Salvos

0 ± 0

3.10 ± 1.40

(0–25)

0.014

Bigeminy

0 ± 0

1.65 ± 0.60

(0–8)

0.014

VT

0 ± 0

0.65 ± 0.33

(0–4)

0.289

RR (sec)

0.20 ± 0.01

0.19 ± 0.01

0.458

QRS (sec)

0.02 ± 0.00

0.02 ± 0.00

0.994

QT (sec)

0.05 ± 0.00

0.06 ± 0.01

0.114

QTc (sec)

0.11 ± 0.01

0.14 ± 0.01

0.033

  1. Values are mean ± SEM with range in parentheses. Episodes of arrhythmias were counted over a 20-min period following surgical instrumentation. SPF = specific-pathogen free; PVCs = premature ventricular contractions; VT = ventricular tachycardia; QTc = Bazett-corrected QT interval. Power (1-β err prob) = 1.00 (Critical t = 1.69, Df = 38, α = 0.05, outcome measure = total arrhythmias).