Table 1 Effects of combination treatment on inhibition of A. fumigatus (NCPF2010) invasion.
Compartment Treated | Days (% Inhibition) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Upper | Lower | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
PC945 (0.1 μg/mL) | DMSO | 86.4 ± 4.47d | 3.36 ± 1.26 | 3.65 ± 0.38 | 4.47 ± 1.27 | 0.30 ± 0.59 | −0.31 ± 2.28 | 0.90 ± 1.65 | 2.76 ± 1.43 |
DMSO | Posaconazole (0.01 μg/mL) | 90.5 ± 2.79d | 15.0 ± 0.96d | 4.14 ± 0.82b | 1.10 ± 0.63 | −0.55 ± 1.86 | −1.13 ± 2.49 | 0.25 ± 0.47 | 0.82 ± 0.28 |
PC945 (0.1 μg/mL) | Posaconazole (0.01 μg/mL) | 98.9 ± 0.03d | 99.1 ± 0.06d | 97.8 ± 0.81d | 91.0 ± 2.56d | 64.1 ± 4.79c | 38.2 ± 8.50 | 2.13 ± 1.5 | 3.73 ± 1.29 |
|  | SRa | 1.00 ± 0.00 | 5.57 ± 0.33 | 13.0 ± 1.16 | 20.6 ± 7.70 | 136 ± 85.6 | 97.2 ± 87.4 | 5.61 ± 5.06 | 1.61 ± 0.63 |
Posaconazole (0.1 μg/mL) | DMSO | 88.4 ± 2.89d | 9.59 ± 3.78b | 1.13 ± 0.51 | −0.26 ± 1.41 | −1.16 ± 1.33 | 0.34 ± 1.50 | −0.06 ± 0.57 | 1.85 ± 1.70 |
DMSO | Posaconazole (0.1 μg/mL) | 95.8 ± 0.61d | 99.1 ± 0.03d | 99.2 ± 0.00d | 99.1 ± 0.07d | 97.5 ± 1.29d | 83.4 ± 9.94d | −4.24 ± 1.25 | 17.2 ± 2.38 |
Posaconazole (0.1 μg/mL) | Posaconazole (0.1 μg/mL) | 95.6 ± 0.69d | 99.2 ± 0.00d | 99.2 ± 0.00d | 99.2 ± 0.00d | 99.0 ± 0.12d | 97.1 ± 0.84d | 9.04 ± 8.24 | 12.3 ± 2.96 |
|  | SRa | 0.96 ± 0.01 | 1.00 ± 0.00 | 1.00 ± 0.00 | 1.00 ± 0.00 | 1.02 ± 0.01 | 1.20 ± 0.16 | 16.4 ± 7.87 | 0.64 ± 0.05 |
Voriconazole (1 μg/mL) | DMSO | 95.0 ± 0.23d | 88.8 ± 6.04d | 59.4 ± 24.7b | 30.8 ± 31.0 | −1.61 ± 1.04 | −1.67 ± 2.31 | −0.55 ± 1.73 | 3.81 ± 1.71 |
DMSO | Voriconazole (1 μg/mL) | 95.9 ± 0.374 | 99.1 ± 0.03d | 99.2 ± 0.07d | 94.8 ± 2.19d | −1.82 ± 1.01 | −0.67 ± 2.92 | 6.92 ± 5.06 | 4.37 ± 3.31 |
Voriconazole (1 μg/mL) | Voriconazole (1 μg/mL) | 95.5 ± 0.00d | 99.1 ± 0.03d | 99.3 ± 0.07d | 94.9 ± 2.13d | −3.13 ± 0.20 | −1.93 ± 3.84 | 7.74 ± 4.98 | 3.33 ± 2.16 |
|  | SRa | 0.96 ± 0.00 | 0.99 ± 0.00 | 1.00 ± 0.00 | 0.98 ± 0.05 | 0.42 ± 0.08 | 0.63 ± 0.13 | 1.34 ± 0.59 | 0.41 ± 0.07 |
