Table 2 Effects of combination treatment on inhibition of multi-azole-resistant TR46/Y121F/T289A A. fumigatus invasion.
Compartment Treated | Days (% Inhibition) | ||||||
|---|---|---|---|---|---|---|---|
Upper | Lower | 1 | 2 | 3 | 4 | 5 | 6 |
PC945 (3 μg/mL) | DMSO | 29.7 ± 2.05c | −0.16 ± 1.97 | −3.12 ± 3.78 | 4.22 ± 1.78 | −12.5 ± 2.99 | 4.64 ± 4.42 |
DMSO | Posaconazole (0.3 μg/mL) | 98.1 ± 0.03c | 81.4 ± 1.83c | 26.9 ± 15.7 | 1.94 ± 1.16 | −10.7 ± 4.73 | 5.94 ± 2.91 |
PC945 (3 μg/mL) | Posaconazole (0.3 μg/mL) | 98.9 ± 0.20c | 96.8 ± 0.44c | 93.8 ± 1.04b | 88.9 ± 4.67c | −7.38 ± 5.02 | 2.78 ± 5.05 |
|  | SRa | 1.00 ± 0.00 | 1.19 ± 0.02 | 6.61 ± 3.45 | 43.2 ± 33.4 | 0.50 ± 0.00 | 1.00 ± 0.00 |
Posaconazole (3 μg/mL) | DMSO | 99.1 ± 0.26c | 97.2 ± 1.33c | 93.6 ± 3.72c | 52.1 ± 15.6b | −6.69 ± 5.22 | 5.78 ± 2.24 |
DMSO | Posaconazole (3 μg/mL) | 99.8 ± 0.12c | 99.9 ± 0.03c | 99.9 ± 0.00c | 99.9 ± 0.03c | 99.8 ± 0.09c | 7.32 ± 1.96 |
Posaconazole (3 μg/mL) | Posaconazole (3 μg/mL) | 99.7 ± 0.13c | 99.9 ± 0.03c | 99.9 ± 0.03c | 99.9 ± 0.03c | 99.7 ± 0.03c | 0.15 ± 1.60 |
|  | SRa | 1.00 ± 0.00 | 1.00 ± 0.00 | 1.00 ± 0.00 | 1.00 ± 0.00 | 1.00 ± 0.00 | 0.07 ± 0.06 |
Voriconazole (10 μg/mL) | DMSO | −4.71 ± 0.90 | 1.57 ± 4.76 | −0.99 ± 4.58 | 2.56 ± 2.10 | −4.04 ± 0.33 | 1.78 ± 3.99 |
DMSO | Voriconazole (10 μg/mL) | 16.1 ± 12.5 | −1.32 ± 1.61 | −1.23 ± 3.92 | −4.06 ± 4.75 | −6.01 ± 5.10 | 6.45 ± 3.96 |
Voriconazole (10 μg/mL) | Voriconazole (10 μg/mL) | 23.1 ± 6.42 | 4.25 ± 2.80 | −5.86 ± 2.90 | −3.97 ± 2.07 | −12.0 ± 1.58 | 5.31 ± 3.19 |
|  | SRa | 17.9 ± 16.8 | 8.75 ± 8.28 | 0.18 ± 0.16 | 0.04 ± 0.01 | 0.41 ± 0.09 | 0.58 ± 0.19 |
