Table 5 Synergistic effects of Neuroticism, Parental depression, Body fat, and Current depressive symptoms with respect to reported lifetime depression.

From: The UKB envirome of depression: from interactions to synergistic effects

I.

I. + II.

I-II. + III.

I-III. + IV.

Neuroticism

Parental depression

Body fat

Current depressive symptoms

 

CR-OR

 

CR-OR

 

CR-OR

 

CR-OR

CI95%

Low

High

Low

0.17

No

0.16

Normal

 

Low

0.16

0.14

0.19

 

Moderate

0.26

0.23

0.31

0.19

High

0.87

0.63

1.21

High

 

Low

0.19

0.16

0.21

 

Moderate

0.43

0.38

0.48

0.28

High

1.50

1.22

1.85

Yes

0.82

Normal

 

Low

0.47

0.32

0.67

 

Moderate

0.61

0.43

0.86

0.61

High

2.50

1.40

4.47

High

 

Low

0.66

0.49

0.89

 

Moderate

1.24

0.98

1.57

1.02

High

2.69

1.66

4.35

Moderate

1.25

No

1.08

Normal

 

Low

0.55

0.44

0.68

 

Moderate

0.68

0.59

0.78

0.77

High

1.68

1.39

2.03

High

 

Low

0.76

0.63

0.91

 

Moderate

1.11

1.00

1.23

1.35

High

2.79

2.47

3.16

Yes

2.33

Normal

 

Low

1.30

0.82

2.04

 

Moderate

1.72

1.32

2.23

1.83

High

3.17

2.12

4.74

High

 

Low

2.04

1.37

3.03

 

Moderate

1.85

1.46

2.35

2.72

High

5.86

4.54

7.57

High

5.60

No

3.93

Normal

 

Low

1.00

0.75

1.34

 

Moderate

1.31

1.14

1.49

2.30

High

3.93

3.55

4.34

High

 

Low

1.72

1.38

2.15

 

Moderate

2.15

1.94

2.38

4.13

High

5.93

5.49

6.4

Yes

6.37

Normal

 

Low

2.26

1.30

3.94

 

Moderate

3.08

2.46

3.86

4.88

High

7.26

6.12

8.62

High

 

Low

2.77

1.71

4.50

 

Moderate

3.89

3.19

4.74

6.96

High

10.11

8.84

11.57