Table 2 Genotypic association of TLR4 and TLR9 gene single nucleotide polymorphisms with HPV 16 and 18 infection.
From: Association of TLR4 and TLR9 polymorphisms and haplotypes with cervical cancer susceptibility
Gene | SNP | Genotype/ Allele | Cases n (%) | ORa (95% CI) | Pa value |
|---|---|---|---|---|---|
TLR4 | rs4986790 | AA | 46 (61.3) | 1 | |
AG | 27 (36) | 1.959 (1.056–3.635) | 0.033 | ||
GG | 2 (2.7) | 2.617 (0.346–19.795) | 0.351 | ||
A | 119 (79.3) | 1 | |||
G | 31 (20.7) | 1.789 (1.055–3.034) | 0.031 | ||
rs10759931 | AA | 13 (17.3) | 1 | ||
AG | 36 (48) | 0.838 (0.380–1.847) | 0.661 | ||
GG | 26 (34.7) | 1.059 (0.458–2.448) | 0.893 | ||
A | 62 (41.3) | 1 | |||
G | 88 (58.7) | 1.065 (0.712–1.591) | 0.760 | ||
rs11536889 | GG | NA | |||
GC | 47 (62.7) | 1 | |||
CC | 28 (37.3) | 1.552 (0.854–2.820) | 0.149 | ||
G | 47 (31.3) | 1 | |||
C | 103 (68.7) | 1.238 (0.812–1.888) | 0.322 | ||
rs1927911 | CC | 28 (37.3) | 1 | ||
CT | 42 (56) | 1.896 (1.055–3.406) | 0.032 | ||
TT | 5 (6.7) | 3.404 (0.852–13.601) | 0.083 | ||
C | 98 (65.3) | 1 | |||
T | 52 (34.7) | 1.653 (1.072–2.549) | 0.023 | ||
TLR9 | rs187084 | TT | 20 (28.1) | 1 | |
TC | 40 (52.1) | 2.915 (1.508–5.635) | 0.001 | ||
CC | 15 (19.7) | 1.793 (0.803–4.002) | 0.154 | ||
T | 80 (53.3) | 1 | |||
C | 70 (46.7) | 1.538 (1.028–2.302) | 0.036 | ||
rs5743836 | TT | 60 (81.7) | 1 | ||
TC | 13 (15.5) | 0.562 (0.277–1.144) | 0.112 | ||
CC | 2 (2.8) | 1.724 (0.236–12.57) | 0.586 | ||
T | 133 (88.7) | 1 | |||
C | 17 (11.3) | 0.723 (0.395–1.322) | 0.292 | ||
rs352140 | GG | 21 (28.1) | 1 | ||
GA | 30 (40.8) | 0.797 (0.403–1.575) | 0.513 | ||
AA | 24 (30.1) | 1.394 (0.659–2.950) | 0.385 | ||
G | 72 (48) | 1 | |||
A | 78 (52) | 1.186 (0.798–1.769) | 0.395 | ||
rs352139 | AA | 15 (18.3) | 1 | ||
AG | 49 (66.2) | 1.589 (0.779–3.241) | 0.203 | ||
GG | 11 (15.5) | 0.610 (0.246–1.511) | 0.285 | ||
A | 79 (52.7) | 1 | |||
G | 71 (47.3) | 0.813 (0.547–1.209) | 0.306 |
