Table 3 Genotypic and allelic association of TLR4 and TLR9 single nucleotide polymorphisms with cervical cancer risk.
From: Association of TLR4 and TLR9 polymorphisms and haplotypes with cervical cancer susceptibility
Gene | SNP | Genotype/ Allele | Cases n (%) | Controls n (%) | ORa (95% CI) | Pa value |
|---|---|---|---|---|---|---|
TLR4 | rs4986790 | AA | 70 (63.6) | 107 (75.9) | 1 | |
AG | 37 (33.6) | 32 (22.7) | 1.767 (1.008–3.097) | 0.0623 | ||
GG | 3 (2.7) | 2 (1.4) | 2.485 (0.397–15.56) | 0.331 | ||
A | 177 (80.4) | 246 (87.2) | 1 | |||
G | 43 (19.6) | 36 (12.8) | 1.693 (1.043–2.747) | 0.033 | ||
rs10759931 | AA | 18 (16.4) | 23 (16.3) | 1 | ||
AG | 48 (43.6) | 75 (54.2) | 0.801 (0.390–1.644) | 0.545 | ||
GG | 44 (40) | 43 (30.5) | 1.295 (0.613–2.735) | 0.498 | ||
A | 84 (38.2) | 121 | 1 | |||
G | 136 (61.8) | 161 | 1.150 (0.801–1.649) | 0.449 | ||
rs11536889 | GC | 63 (57.3) | 102 (72.3) | 1 | ||
CC | 47 (42.7) | 39 (27.7) | 1.948 (1.149–3.305) | 0.013 | ||
G | 63 (28.6) | 102 | 1 | |||
C | 157 (71.4) | 180 | 1.385 (0.946–2.027) | 0.094 | ||
rs1927911 | CC | 37 (33.6) | 76 (54.3) | 1 | ||
CT | 66 (60) | 60 (42.9) | 2.248 (1.328–3.806) | 0.003 | ||
TT | 7 (6.4) | 5 (2.9) | 3.595 (0.989–13.064) | 0.052 | ||
C | 140 (63.6) | 212 (75.2) | 1 | |||
T | 80 (36.4) | 70 (24.8) | 1.635 (1.109–2.410) | 0.013 | ||
TLR9 | rs187084 | TT | 28 (25.5) | 67 (47.5) | 1 | |
TC | 58 (52.7) | 46 (32.6) | 3.004 (1.668–5.413) | 0.000 | ||
CC | 24 (21.8) | 28 (19.9) | 2.040 (1.009–4.126) | 0.049 | ||
T | 114 (51.8) | 180 (63.8) | 1 | |||
C | 106 (48.2) | 102 (36.2) | 1.495 (1.042–2.143) | 0.029 | ||
rs5743836 | TT | 89 (80.9) | 100(70.9) | 1 | ||
TC | 19 (17.3) | 39 (27.7) | 0.553 (0.297–1.029) | 0.061 | ||
CC | 2 (1.8) | 2 (1.4) | 1.160 (0.159–8.474) | 0.883 | ||
T | 197 (89.5) | 239 (84.7) | 1 | |||
C | 23 (10.5) | 43 (15.3) | 0.704 (0.408–1.216) | 0.208 | ||
rs352140 | GG | 32 (29.1) | 39 (27.7) | 1 | ||
GA | 45 (40.9) | 70 (49.6) | 0.782 (0.430–1.425) | 0.422 | ||
AA | 33 (30) | 32 (22.7) | 1.255 (0.639–2.464) | 0.510 | ||
G | 109 (49.5) | 148 (52.5) | 1 | |||
A | 111 (50.5) | 134 (47.5) | 1.165 (0.818–1.660) | 0.397 | ||
rs352139 | AA | 23 (20.9) | 33 (23.4) | 1 | ||
AG | 73 (66.4) | 68 (48.2) | 1.548 (0.826–2.900) | 0.172 | ||
GG | 14 (12.7) | 40 (28.4) | 0.509 (0.226–1.147) | 0.103 | ||
A | 119 (54) | 134 (47.5) | 1 | |||
G | 101 (46) | 148 (52.5) | 0.759 (0.532–1.084) | 0.129 |
