Table 1 Effect of the inhibition of Gal-3 on cardiac parameters in IR rats.

From: Myocardial Injury After Ischemia/Reperfusion Is Attenuated By Pharmacological Galectin-3 Inhibition

 

Sham

IR

IR + MCP

Weights

n = 10

n = 12

n = 10

Body (g)

323 ± 5

297 ± 7*

294 ± 8*

Heart (mg)

1036 ± 22

974 ± 27

992 ± 31

LV (mg)

719 ± 17

691 ± 21

698 ± 22

HW/BW (mg/g)

3.21 ± 0.06

3.29 ± 0.09

3.38 ± 0.06

LVW/BW (mg/g)

2.23 ± 0.05

2.33 ± 0.06

2.38 ± 0.05

Function (MRI)

n = 10

n = 9

n = 9

HR (bpm)

403 ± 11

349 ± 12*

343 ± 18*

LVESV (μl)

102 ± 5

190 ± 15***

224 ± 22***

LVEDV (μl)

352 ± 14

433 ± 22*

466 ± 32**

EF (%)

71 ± 1

57 ± 2***

52 ± 2***

SV (µl)

250 ± 10

244 ± 12

242 ± 17

CO (ml/min)

100 ± 3

84 ± 4*

83 ± 6*

Perfusion (MRI)

n = 10

n = 10

n = 10

LV perf (ml/mg/min)

6.09 ± 0.19

3.64 ± 0.15***

4.27 ± 0.14***,†

Septum perf (ml/mg/min)

6.35 ± 0.22

3.75 ± 0.17***

4.60 ± 0.17***,††

Hemodynamics

n = 8

n = 8

n = 7

HR (bpm)

417 ± 14

394 ± 14

379 ± 13

SBP (mmHg)

132 ± 5

124 ± 5

121 ± 3

DBP (mmHg)

94 ± 4

92 ± 5

90 ± 3

LVESP

125.7 ± 3.2

121.9 ± 5.9

111.9 ± 5.3

LVEDP

2.2 ± 0.5

4.0 ± 0.9

2.9 ± 0.7

dP/dt max

9784 ± 294

8283 ± 452

7968 ± 572*

dP/dt min

8504 ± 392

6889 ± 362*

6591 ± 321**

LVESPVR

24.38 ± 0.98

17.83 ± 0.90***

17.19 ± 0.91***

LVEDPVR

0.82 ± 0.09

2.32 ± 0.30***

1.51 ± 0.12†

Tau e

5.34 ± 0.20

7.63 ± 0.32***

6.71 ± 0.43*

Tau 1/2

4.19 ± 0.18

5.29 ± 0.38*

4.44 ± 0.22

Serum parameters

n = 10

n = 10

n = 10

BNP (AU)

0.16 ± 0.014

0.26 ± 0.024*

0.19 ± 0.024†

IL-1 β (AU)

127 ± 14

184 ± 12*

139 ± 11†

CRP (AU)

2667 ± 410

4231 ± 425*

2436 ± 235†

Hemodynamics

n = 8

n = 8

n = 7

HR (bpm)

417 ± 14

394 ± 14

379 ± 13

SBP (mmHg)

132 ± 5

124 ± 5

121 ± 3

DBP (mmHg)

94 ± 4

92 ± 5

90 ± 3

LVESP

125.7 ± 3.2

121.9 ± 5.9

111.9 ± 5.3

LVEDP

2.2 ± 0.5

4.0 ± 0.9

2.9 ± 0.7

dP/dt max

9784 ± 294

8283 ± 452

7968 ± 572*

dP/dt min

8504 ± 392

6889 ± 362*

6591 ± 321**

LVESPVR

24.38 ± 0.98

17.83 ± 0.90***

17.19 ± 0.91***

LVEDPVR

0.82 ± 0.09

2.32 ± 0.30***

1.51 ± 0.12†

Tau e

5.34 ± 0.20

7.63 ± 0.32***

6.71 ± 0.43*

Tau 1/2

4.19 ± 0.18

5.29 ± 0.38*

4.44 ± 0.22

Serum parameters

n = 10

n = 10

n = 10

BNP (AU)

0.16 ± 0.014

0.26 ± 0.024*

0.19 ± 0.024†

IL-1 β (AU)

127 ± 14

184 ± 12*

139 ± 11†

CRP (AU)

2667 ± 410

4231 ± 425*

2436 ± 235†

  1. IR: ischemia reperfusion; MCP: modified citrus pectin; LV: Left ventricle; LVW: LV weight; BW: Body weight; HW: heart weight; HR: heart rate; LVESV: LV end-systolic volume; LVEDV: LV end-diastolic volume; EF: ejection fraction; SV: stroke volume; CO: cardiac output; SBP: systolic blood pressure; DBP: diastolic blood pressure; LVESP: LV end-systolic pressure; LVEDP: LV end-diastolic pressure; LVESPVR: LV end-systolic pressure-volume relation; LVEDPVR: LV end-diastolic pressure-volume relation; BNP: bran natriuretic peptide; IL-1 β: interleukin-1 beta; CRP: C-reactive protein. Data values represent mean ± SEM number of rats per group is indicated in each column. *p < 0.05, **p < 0.01 *** p < 0.001 vs. control group; †p < 0.05 vs. IR group. Anova plus Tukey for weight and functional measurements and plus Bonferroni for protein quantification.
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