Figure 2 | Scientific Reports

Figure 2

From: Synergistic mechanisms of Sanghuang–Danshen phytochemicals on postprandial vascular dysfunction in healthy subjects: A network biology approach based on a clinical trial

Figure 2

Biochemical, genetic and metabolic changes over 6 h, in blood samples taken after consumption of placebo (○) or SD (● 300, ▲ 600 and ■ 900 mg) together with a high-fat-load in healthy subjects. (A) Triglyceride and insulin levels in plasma, and the collagen/epinephrine-induced closure time in whole blood; (B) COX-1, COX-2, VCAM-1 and ICAM-1 gene expressions in PBMCs; (C) PCA and OPLS-DA score plots derived from GC–TOF–MS metabolites in plasma; and (D) heat map of differentially changed metabolites. COX, cyclooxygenase; ICAM-1, intercellular adhesion molecule-1; OPLS-DA, orthogonal partial least squares-discriminant; PBMCs, peripheral blood mononuclear cells; PCA, principal component analysis; analysis; SD, Sanghuang–Danshen; VCAM-1, vascular cell adhesion molecule-1. Values are expressed as mean ± SEM. The different letters indicate significant differences at P < 0.05.

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