Figure 1 | Scientific Reports

Figure 1

From: Blockade of L-type Ca2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-κB pathway

Figure 1

DOX induced phosphorylation of CaMKII and NF-κB and increased cleaved caspase 3 in cardiomyocytes in a dose-dependent manner. (a) Representative immunoblots of CaMKII, phosphorylated CaMKII, NF-κB, phosphorylated NF-κB, cleaved caspase 3, and GAPDH in cultured neonatal rat ventricular myocytes (NRVMs) treated with indicated concentrations of DOX. (b–d) Quantitative analysis of phosphorylated CaMKII, phosphorylated NF-κB, and cleaved caspase 3 in NRVMs treated with indicated concentration of DOX (n = 5). The experiment was conducted 2 times. *P < 0.05: post-hoc Tukey’s comparison test.

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