Figure 8
Blockade of LTCC attenuated DOX-induced cardiac dysfunction and loss of heart weight in mice. (a) The representative echocardiographic images of DOX (3 doses of DOX at 6 mg/kg body weight every third day for 1 week) or control vehicle (phosphate-buffered saline: PBS) treated-C57B/6 J mouse hearts subjected to either nifedipine (Nif, 10 mg/day/day) or saline for 14 days. Long two-way arrows and short two-way arrows indicate left ventricular end-diastolic diameter (LVDd) and left ventricular end-systolic diameter (LVDs), respectively. (b–f) Heart rate, LVDd and LVDs, fractional shortening, and LV ejection fraction measured by echocardiography at day14 in each group (n = 6–14). (g,h) Heart weight to tibial length (TL) ratio and LV weight to TL ratio in each group (n = 6–14). *P < 0.05, **P < 0.01: post-hoc Tukey’s comparison test.
