Figure 2 | Scientific Reports

Figure 2

From: Transcription Factors Regulation in Human Peripheral White Blood Cells during Hypobaric Hypoxia Exposure: an in-vivo experimental study

Figure 2

Relative quantification of mRNA levels and protein plasma levels for pro-inflammatory cytokines in white blood cells reveal a slight increase in inflammatory state during HH exposure. (A,B) IL-1β and IL-6 mRNA quantification don’t reveal significant variation in mRNA production for both cytokines during hypoxia stimulus over time. The results of mRNA are the average of the values assessed after three reaction tests. Relative quantification of mRNA expression for pro-inflammatory cytokines was calculated as fold change using the 2−(ΔΔCt) method. Values are mean ± SD. (C,D) Only IL-1β circulating protein showed a slight transient increase after 24 h of HH exposure. The absolute values for both circulating proteins are in the normal range for general population. The median (continuous band) and the mean (dotted band) are represented inside the boxes. *P < 0.05 after Bonferroni correction.

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