Table 1 Differential Expression Analyses in FTLD-U Cases.

From: Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia

Gene Name

Raw P-value

FDR Corrected P-value

SE

Beta

HNF4A

2.16E-05

1.25E-03

0.195

−1.53

NR5A

1.84E-04

3.55E-03

0.199

−1.31

TAL1

9.96E-05

2.89E-03

0.287

−1.37

SLC2A4

7.36E-04

0.01

0.237

−1.16

PSEN1

2.12E-03

0.02

0.605

1.04

KRT81

3.63E-03

0.03

0.293

−0.981

MYBL2

3.13E-03

0.03

0.251

−0.999

UBE2I

3.51E-03

0.03

0.284

−0.985

EBI3

4.64E-03

0.03

0.375

−0.952

BATF

6.06E-03

0.03

0.256

−0.920

ARFRP1

6.57E-03

0.03

0.240

−0.910

NR6A1

0.01

0.04

0.218

−0.860

PACS1

0.01

0.04

0.192

−0.855

PELP1

0.01

0.04

0.246

−0.8.71

TEF

0.01

0.05

0.109

−0.835

  1. Expression analyses revealed 15 out of 64 genes in our svPPA network showed dysregulated expression in pathologically confirmed cases of frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) when compared to age-matched controls. P-values for the top associated probe for each gene (FDR corrected p < 0.05 to account for multiple testing) are shown. FDR – false discovery rate.
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