Table 1 List of genes analysed in the study, their functions, and the TaqMan Gene Expression assays used in the expression experiments (Life Technologies).
Gene | Function | Functional Group | TaqMan Assay |
|---|---|---|---|
IL12A | Pro-inflammatory cytokine | Inflammation/Damage Direct | Hs00222327_ml |
IL21 | Pleiotropic cytokine | Inflammation/Damage Direct | Hs00168405_ml |
NFKB1 | Regulation of autoimmunity and inflammation | Inflammation/Damage Direct | Hs00765730_m1 |
C-REL | Subunit of the NF-kB transcription complex | Inflammation/Damage Direct | Hs00968436_m1 |
TNFAIP3 | Negative feedback loop control of NF-kB | Inflammation/Damage Direct | Hs00234713_m1 |
KIAA1109 | Located in the genomic region associated with CeD | Canidated/Associated | Hs00361070_ml |
SH2B3 | Activates PI3-kinase | Inflammation/Damage Regulation | Hs00193878_m1 |
RGS1 | Lymphocytes Homing | Inflammation/Damage Regulation | Hs00175260_m1 |
TAGAP | Negative regulator of the immune response | Inflammation/Damage Regulation | Hs00611823_m1 |
TNFRSF14 | Activation of NK intestinal and CD4 + T cells, “gut-homing cells” | Inflammation/Damage Regulation | Hs00998604_ml |
TNFSF14 | Activation of NK intestinal and CD4 + T cells, “gut-homing cells” | Inflammation/Damage Regulation | Hs00542477_m1 |
LPP | Extracellular matrix and cell-cell contact homeostasis | Cell Adhesion/Integrity of Intestinal Barrier | Hs00944352_m1 |
TJP1 | Proteins of the tight junctions involved in maintaining the integrity of the intestinal barrier | Cell Adhesion/Integrity of Intestinal Barrier | Hs01551861_ml |
PTPRK | Maintenance of cell junctions and participation in the modulation of EGFR activity, resulting in an inhibition of cell proliferation | Cell Adhesion/Integrity of Intestinal Barrier | Hs00267788_ml |
ARHGAP31 | Regulation of cell migration, focal adhesion size and dynamics | Cell Adhesion/Integrity of Intestinal Barrier | Hs00393361_ml |
C1orf106 | Involved in cell adhesion processes | Cell Adhesion/Integrity of Intestinal Barrier | Hs01009089_ml |
