Figure 6 | Scientific Reports

Figure 6

From: Different Antioxidant Efficacy of Two MnII-Containing Superoxide Anion Scavengers on Hypoxia/Reoxygenation-Exposed Cardiac Muscle Cells

Figure 6

Time-related permeation of MnQ2 and MnM2 into H9c2 cell fractions evaluated as intracellular Mn amounts. The pellet fraction contains mitochondria whereas the supernatant fraction corresponds to cytosol. Upon incubation with MnQ2 (10 μmol L−1), Mn rises steadily in both cell fractions since 30 min. Upon incubation with MnM2 (10 μmol L−1), Mn also rises steadily in the cytosolic fraction but shows a time-related increase in the mitochondrial fraction. In this fraction, Mn was significantly higher with MnQ2 than with MnM2 at every time point. ***p < 0.001, *p < 0.05 (two-way ANOVA).

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