Figure 2 | Scientific Reports

Figure 2

From: Characterization of two putative Dichelobacter nodosus footrot vaccine antigens identifies the first lysozyme inhibitor in the genus

Figure 2

Homology model of Dn-MIP based on the structure of Legionella pneumophila Mip (PDB:1FD9). The dimerization domain is shown in the zoom, forming around a hydrophobic core. The dimerisation structure of Legionella template (PDB:1FD9, shown in turquoise and light blue) and D. nodosus model (shown in gold and orange) are similar overall structure with conserved secondary structure but some changes in the loops connecting secondary structure elements. While the dimer forms around a hydrophobic core, two key polar interactions stabilising the dimer are highlighted. A second zoom shows the catalytic domain in surface presentation with the electric potential mapped onto the surface (blue, positive; red, negative). The position of the inhibitor FK506, taken from the human FKBP protein (PDB:1BKF), indicates presence of the binding pocket in Dn-MIP.

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