Figure 1

HCV infection skewed cTfh cells toward CXCR3⁺ cTfh differentiation. (A) Representative flow cytometry plots of the gating strategy of CXCR3⁺ cTfh and CXCR3⁻ cTfh cells. (B–E) Comparison of the percentages of cTfh, CXCR3⁺ cTfh, and CXCR3⁻ cTfh cells as well as the ratio of CXCR3⁺/CXCR3⁻ cTfh cells among CD4⁺ T cells between healthy controls (HC, n = 28) and HCV-infected individuals (HCV, n = 38). The data are shown as the median and interquartile range. The Mann-Whitney U test was used for comparisons between two groups.