Table 3 Number and proportion of patients tested positive at (a) the first and (b) subsequent LTBI tests, and the associations of factors in simple logistic regression model, unless otherwise specified.

From: A longitudinal study on latent TB infection screening and its association with TB incidence in HIV patients

	the first LTBI test (n = 1740)					subsequent LTBI tests^& (n = 1516)
	no. of +ve	N	% of +ve	OR	95% C.I.	no. of +ve	N	% of +ve	OR	95% C.I.
LBTI test	224	1740	13%			325	1516	21%
Socio-demographics
Gender
Female	30	254	12%	ref		43	224	19%	ref
Male	194	1486	13%	1.12	0.74 to 1.69	282	1292	22%	1.18	0.82 to 1.68
Ethnicity
Non-Chinese	71	379	19%	ref		48	308	16%	ref
Chinese	153	1361	11%	0.55	0.4 to 0.75	277	1208	23%	1.61	1.15 to 2.25
Local residence
No	39	136	29%	ref		12	97	12%	ref
Yes	185	1604	12%	0.32	0.22 to 0.48	313	1419	22%	2.00	1.08 to 3.72
Conditions at LTBI test
Median age (years old); (IQR)
LTBI −ve	36	1516	(30 to 43)	ref	U test	40	1189	(33 to 49)	ref	U test
LTBI +ve	36	224	(30 to 43)	p = 0.93		42	325	(36 to 48)	p = 0.15
Median CD4 (/μL); (IQR)
LTBI −ve	310	1513	(175 to 470)	ref	U test	484	1184	(357 to 647)	ref	U test
LTBI +ve	378	223	(262 to 597)	p < 0.001		506	325	(381 to 636)	p = 0.22
Median CD4/CD8 ratio; (IQR)
LTBI −ve	0.40	1512	(0.25 to 0.66)	ref	U test	0.56	1184	(0.40 to 0.82)	ref	U test
LTBI +ve	0.45	223	(0.29 to 0.63)	p = 0.16		0.58	325	(0.40 to 0.81)	p = 0.67
Diabetes mellitus diagnosis ^#
No	213	1657	13%	ref		307	1444	21%	ref
Yes	11	83	13%	1.04	0.54 to 1.99	18	72	25%	1.23	0.71 to 2.14
on HAART ^#
No	44	153	29%	ref		10	109	9%	ref
Yes	180	1587	11%	0.32	0.22 to 0.46	315	1407	22%	2.86	1.47 to 5.54
Median months from HAART; (IQR)
LTBI −ve	−1.43	1412	(−15.53 to 0.43)	ref	U test	43.60	1095	(18.17 to 71.13)	ref	U test
LBTI +ve	−12.08	190	(−36.79 to 0.58)	p < 0.001		33.97	315	(16.73 to 59.07)	p = 0.001
ADI diagnosis ^#
No	205	1475	14%	ref		281	1270	22%	ref
Yes	19	265	7%	0.48	0.29 to 0.78	44	246	18%	0.77	0.54 to 1.09
Eventually developed TB
No	199	1687	12%	ref		320	1488	22%	ref
Yes	25	53	47%	6.68	3.82 to 11.68	5	28	18%	0.79	0.3 to 2.1

Bold – variables have a significant association (p < 0.05) with the outcome.
^#Occurrence of the respective factor after TB disease development excluded.
^&For patients with all negative LTBI testing results, the last test was selected for analysis.
ADI – AIDS defining illness; HAART – highly active antiretroviral therapy; LTBI – latent TB infection; U test –Mann–Whitney U test.

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Table 3 Number and proportion of patients tested positive at (a) the first and (b) subsequent LTBI tests, and the associations of factors in simple logistic regression model, unless otherwise specified.

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