Figure 5 | Scientific Reports

Figure 5

From: Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform

Figure 5

RSU-1-X1 depletion reduces cell invasion, that of RSU-1L enhances it and silencing both decreases it. (a–h) Transwell invasion assay performed in MCF-7 and MDA-MB-231-LM2 cells transfected with Non Specific control (NSC) siRNA and control shRNA (a,e), control shRNA and RSU-1-X1 siRNA (b,f), RSU-1LshRNA and control NSC siRNA (c,g) and both RSU-1X1 siRNA and RSU-1L-shRNA (d,h,i) Quantification of the cell invasion results from two independent experiments run in duplicates. Asterisks denote statistical significant differences (*p value < 0.05, **p value < 0.01, ***p value < 0.001).

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