Figure 6 | Scientific Reports

Figure 6

From: Poorly controlled diabetes during pregnancy and lactation activates the Foxo1 pathway and causes glucose intolerance in adult offspring

Figure 6

Phosphorylation of Foxo1, Akt, and Erk in the liver of STZ male offspring. Western blotting was performed using antibodies against phospho-Foxo1 and Foxo1 (A), phospho-Akt and Akt (B), and phospho-Erk and Erk (C). An anti-β-actin antibody was used for normalisation. Total protein was obtained from the liver of offspring at 26–27 weeks (n = 4 for each CTR and STZ offspring). The average level in CTR offspring was set as 1. Data represent the mean ± SE. *P < 0.05, **P < 0.01, ***P < 0.001, N.S. not significant. Full-length blots are presented in Supplementary Fig. 4.

Back to article page